Afatinib dimaleate
|
- $8 - $2200
- Product name: Afatinib dimaleate
- CAS: 850140-73-7
- MF: C28H29ClFN5O7
- MW: 602.02
- EINECS:810-416-1
- MDL Number:MFCD28969755
- Synonyms:BIBW2992-MA2;Afatinib (diMaleate), BIBW2992;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-, (2Z)-2-butenedioate (1:2);(2E)-N-(4-[(3-chloro-4-fluorophenyl)aMino]-7-{[(3S);Afatinib double Maleate;Afatinib (BIBW2992) Dimaleate;N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-(2E)-2-butenamide,(2Z)-2-butenedioate (1:2);Afatinib dimaleate BIBW 2992MA2
77 prices
Selected condition：
Brand
- A1 Biochem Labs
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
Package
- 25mg
- 500mg
- 1000mg
- 200mg
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO
- 50
- 1.00g
- 5.00g
- 10
- 25.00g
- 1mg
- 10mM(in 1mL DMSO)
- 10mM(in1mLDMSO)
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- 5G
- 25g
- ManufacturerA1 Biochem Labs
- Product number6566399
- Product descriptionAfatinib(dimaleate) 98%
- Packaging5G
- Price$450
- Updated2021-12-16
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging250mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging100mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging50mg
- Price$15
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging10mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging1mg
- Price$8
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging25g
- Price$718
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging1g
- Price$50
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038YP
- Product descriptionAfatinib Dimaleate 98%
- Packaging5g
- Price$162
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15408
- Product descriptionAfatinib dimaleate 98%
- Packaging100MG
- Price$160
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15408
- Product descriptionAfatinib dimaleate 98%
- Packaging5G
- Price$1960
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15408
- Product descriptionAfatinib dimaleate 98%
- Packaging1G
- Price$490
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3423AH
- Product descriptionAfatinibDimaleate
- Packaging250mg
- Price$159
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinib dimaleate
- Packaging50mg
- Price$125
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinib dimaleate
- Packaging5mg
- Price$53
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3145
- Product descriptionAfatinibdimaleate
- Packaging5mg
- Price$41
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A1 Biochem Labs | 6566399 | Afatinib(dimaleate) 98% | 5G | $450 | 2021-12-16 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 250mg | $22 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 100mg | $18 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 50mg | $15 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 10mg | $12 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 1mg | $8 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 25g | $718 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 1g | $50 | 2026-05-28 | Buy |
| aablocks | AA0038YP | Afatinib Dimaleate 98% | 5g | $162 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15408 | Afatinib dimaleate 98% | 100MG | $160 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15408 | Afatinib dimaleate 98% | 5G | $1960 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15408 | Afatinib dimaleate 98% | 1G | $490 | 2026-05-27 | Buy |
| AK Scientific | 3423AH | AfatinibDimaleate | 250mg | $159 | 2021-12-16 | Buy |
| ApexBio Technology | A3145 | Afatinib dimaleate | 50mg | $125 | 2026-05-06 | Buy |
| ApexBio Technology | A3145 | Afatinib dimaleate | 5mg | $53 | 2026-05-06 | Buy |
| ApexBio Technology | A3145 | Afatinibdimaleate | 5mg | $41 | 2021-12-16 | Buy |
Properties
Melting point :>237oC (dec.)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Pale Yellow
Water Solubility :H2O: 2mg/mL, clear
InChIKey :LIENDGDDWJRJLO-LBXKZPGENA-N
SMILES :C(/C(=O)O)=C/C(=O)O.N(C1C=CC(F)=C(Cl)C=1)C1=NC=NC2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC1=2 |&1:25,r|
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Pale Yellow
Water Solubility :H2O: 2mg/mL, clear
InChIKey :LIENDGDDWJRJLO-LBXKZPGENA-N
SMILES :C(/C(=O)O)=C/C(=O)O.N(C1C=CC(F)=C(Cl)C=1)C1=NC=NC2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC1=2 |&1:25,r|
Safety Information
| Symbol(GHS): |
 
|
||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Afatinib dimaleate was approved by the U.S. Food and Drug Administration (FDA) in 2013 for the treatment of non-small cell lung cancer (NSCLC). Specifically, it was approved for patients presenting with metastatic NSCLC tumors which contain epidermal growth factor receptor (EGFR) exon deletions or exon 21 mutations. Afatinib dimaleate is a covalent inhibitor of ErbB tyrosine kinases (tyk), which downregulates ErbB signaling by irreversible binding of EGFR tyk binding sites. While no manufacturing route has been disclosed to date, the most scalable published route likely derives from two Boehringer Ingelheim patents.More related product prices
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- 162012-69-3 Afatinib (BIBW 2992) 86087-23-2 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Afatinib (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine trans-4-Dimethylaminocrotonic acid hydrochloride Olaparib Nintedanib Ethanesulfonate Salt PLERIXAFOR Crizotinib 918504-65-1Related product price
-
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
$8-1850 -
162012-69-3
$5-1252.83 -
Afatinib (BIBW 2992)
$10-2658.8
Suppliers and manufacturers
Hebei Yanxi Chemical Co., Ltd.
Shanghai Famo Biotech Co Ltd
Guangzhou Tosun Pharmaceutical Ltd
Frapp's ChemicalNFTZ Co., Ltd.
Capot Chemical Co.,Ltd.
Beijing Cooperate Pharmaceutical Co.,Ltd
Shanghai Bojing Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
BIBW2992 DiMaleate
CAS:850140-73-7
