(+)-Bicuculline
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- $18 - $8100
- Product name: (+)-Bicuculline
- CAS: 485-49-4
- MF: C20H17NO6
- MW: 367.35
- EINECS:207-619-7
- MDL Number:MFCD00005006
- Synonyms:5-g)isoquinolin-5-yl)-,(r-(r*,s*))-lo( ;d-Bicuculline/(+)-Bicuculline;D-alkali than buttoned Spirit;Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-;6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one;furo(3,4-e)-1,3-benzodioxol-8(6h)-one,6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxo ;(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one;NSC 3219
96 prices
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Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- JR MediChem
- Sigma-Aldrich
- TCI Chemical
- TRC
- Usbiological
Package
- 0.5g
- 1000mg
- 2g
- 2000mg
- 2.5g
- 5000mg
- 5g
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mlx10mM(inDMSO)
- 10g
- 10000mg
- 10mM*1mLinDMSO(Solution)
- 5mg
- 10mg
- 20mg
- 10mM(in1mLDMSO)
- 25mg
- 50mg
- 100mg
- 250MG
- 1G
- 10mM(in 1mL DMSO)
- 500mg
- Manufactureraablocks
- Product numberAA00DED7
- Product description(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one 95%
- Packaging5mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DED7
- Product description(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one ≥98%
- Packaging25mg
- Price$33
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DED7
- Product description(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one ≥98%
- Packaging50mg
- Price$49
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DED7
- Product description(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one
- Packaging100mg
- Price$92
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DED7
- Product description(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one ≥98%
- Packaging500mg
- Price$376
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberU103988
- Product descriptionBicuculline 98.00%
- Packaging250MG
- Price$200
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU103988
- Product descriptionBicuculline 98.00%
- Packaging1G
- Price$670
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-B0239-M500
- Product description(+)-Bicuculline ≥99%(HPLC)
- Packaging500mg
- Price$406
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-B0239-M500
- Product description(+)-Bicuculline ≥99%(HPLC)
- Packaging500mg
- Price$215
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-B0239-M025
- Product description(+)-Bicuculline ≥99%(HPLC)
- Packaging25mg
- Price$75
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberV0271
- Product description(+)-Bicuculline
- Packaging25mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberV0271
- Product description(+)-Bicuculline
- Packaging100mg
- Price$191
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberN1592
- Product description(+)-Bicuculline
- Packaging250mg
- Price$220
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberN1592
- Product description(+)-Bicuculline
- Packaging10mM(in1mLDMSO)
- Price$116
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberN1592
- Product description(+)-Bicuculline
- Packaging250mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberN1592
- Product description(+)-Bicuculline
- Packaging100mg
- Price$100
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00DED7 | (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one 95% | 5mg | $18 | 2026-05-28 | Buy |
| aablocks | AA00DED7 | (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one ≥98% | 25mg | $33 | 2026-05-28 | Buy |
| aablocks | AA00DED7 | (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one ≥98% | 50mg | $49 | 2026-05-28 | Buy |
| aablocks | AA00DED7 | (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one | 100mg | $92 | 2026-05-28 | Buy |
| aablocks | AA00DED7 | (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one ≥98% | 500mg | $376 | 2026-05-28 | Buy |
| ACHEMBLOCK | U103988 | Bicuculline 98.00% | 250MG | $200 | 2026-05-27 | Buy |
| ACHEMBLOCK | U103988 | Bicuculline 98.00% | 1G | $670 | 2026-05-27 | Buy |
| Adipogen Life Sciences | CDX-B0239-M500 | (+)-Bicuculline ≥99%(HPLC) | 500mg | $406 | 2026-05-06 | Buy |
| Adipogen Life Sciences | CDX-B0239-M500 | (+)-Bicuculline ≥99%(HPLC) | 500mg | $215 | 2021-12-16 | Buy |
| Adipogen Life Sciences | CDX-B0239-M025 | (+)-Bicuculline ≥99%(HPLC) | 25mg | $75 | 2026-05-06 | Buy |
| AK Scientific | V0271 | (+)-Bicuculline | 25mg | $70 | 2021-12-16 | Buy |
| AK Scientific | V0271 | (+)-Bicuculline | 100mg | $191 | 2021-12-16 | Buy |
| ApexBio Technology | N1592 | (+)-Bicuculline | 250mg | $220 | 2026-05-06 | Buy |
| ApexBio Technology | N1592 | (+)-Bicuculline | 10mM(in1mLDMSO) | $116 | 2026-05-06 | Buy |
| ApexBio Technology | N1592 | (+)-Bicuculline | 250mg | $200 | 2021-12-16 | Buy |
| ApexBio Technology | N1592 | (+)-Bicuculline | 100mg | $100 | 2021-12-16 | Buy |
Properties
Melting point :193-197 °C
alpha :D25 +130.5° (CHCl3)
Boiling point :497.92°C (rough estimate)
Density :1.3694 (rough estimate)
refractive index :1.5600 (estimate)
storage temp. :2-8°C
solubility :Benzene, Chloroform, DMSO, Ethyl Acetate
pka :4.84(at 25℃)
form :Off-white to yellow powder.
color :Pale Yellow
optical activity :[α]20/D +126±6°, c = 1% in chloroform
λmax :325nm(lit.)
Merck :14,1203
BRN :98786
InChI :1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChIKey :IYGYMKDQCDOMRE-ZWKOTPCHSA-N
SMILES :[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]4([H])N(C)CCc5cc6OCOc6cc45
CAS DataBase Reference :485-49-4(CAS DataBase Reference)
EPA Substance Registry System :Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)
alpha :D25 +130.5° (CHCl3)
Boiling point :497.92°C (rough estimate)
Density :1.3694 (rough estimate)
refractive index :1.5600 (estimate)
storage temp. :2-8°C
solubility :Benzene, Chloroform, DMSO, Ethyl Acetate
pka :4.84(at 25℃)
form :Off-white to yellow powder.
color :Pale Yellow
optical activity :[α]20/D +126±6°, c = 1% in chloroform
λmax :325nm(lit.)
Merck :14,1203
BRN :98786
InChI :1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChIKey :IYGYMKDQCDOMRE-ZWKOTPCHSA-N
SMILES :[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]4([H])N(C)CCc5cc6OCOc6cc45
CAS DataBase Reference :485-49-4(CAS DataBase Reference)
EPA Substance Registry System :Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs. Bicuculline is a competitive GABAA receptor antagonist that can act as an allosteric inhibitor at GABAA receptors. At 100 μM, it blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons. Bicuculline also reversibly blocks GABAA receptors on horizontal cells in the mouse retina with an IC50 value of 1.7 μM. By blocking the inhibitory action of GABA, bicuculline mimics the action of epilepsy and is widely used in experimental studies as a convulsant, inducing seizure in hippocampal or cortical neurons in prepared brain slices.More related product prices
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Suppliers and manufacturers
Shanghai Standard Technology Co., Ltd.
Shanghai Zheyan Biotech Co., Ltd.
Chengdu Biopurify Phytochemicals Ltd.
Nanjing Dolon Biotechnology Co.,Ltd.
CONIER CHEM AND PHARMA LIMITED
Wuhan ChemNorm Biotech Co.,Ltd.
Hubei Ipure Biology Co., Ltd
Hefei TNJ Chemical Industry Co.,Ltd.
(+)-Bicuculline
CAS:485-49-4
