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ChemicalBook >> CAS DataBase List >> CHIR-99021

CHIR-99021

$28 - $4401
Product name: CHIR-99021
CAS: 252917-06-9
MF: C22H18Cl2N8
MW: 465.34
EINECS:809-015-4
MDL Number:MFCD11846251
Synonyms:6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile;6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile;CHIR-99021;GSK-3 Inhibitor XVI;3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino];CT 99021(CHIR 99021);6-[2-[4-(2,4-Dichlorophenyl)-5-(4-Methyl-1H-iMidazol-2-yl)pyriMidin-2-ylaMino]ethylaMino]pyridine-3-;CHIR 99021(CT 99021)

Price143 Properties Safety Information Description

143 prices

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Brand

aablocks
ACHEMBLOCK
AK Scientific
Ambeed
ApexBio Technology
Apolloscientific
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
CSNpharm
DC Chemicals
Matrix Scientific
Medical Isotopes, Inc.
Sigma-Aldrich
TCI Chemical
Tocris
TRC
Usbiological

Package

2mg
5MG
10mg
EvaluationSample
10mM*1mLinDMSO(Solution)
10mM*1mLinDMSO(Solid+Solvent)
50
1unit
10
1mg
10mM*1mLinDMSO
25mg
2x25mg
50mg
100mg
200mg
250.00mg
250mg
1g
1.00g
5g
10mM(in1mLDMSO)

Manufactureraablocks
Product numberAA00382I
Product description[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%
Packaging25mg
Price$28
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00382I
Product description[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%
Packaging50mg
Price$48
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00382I
Product description[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%
Packaging100mg
Price$72
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00382I
Product description[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%
Packaging250mg
Price$116
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00382I
Product description[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%
Packaging1g
Price$266
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00382I
Product description[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%
Packaging5g
Price$840
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product number10303
Product descriptionCHIR99021 98%
Packaging1G
Price$750
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product number10303
Product descriptionCHIR99021 98%
Packaging100MG
Price$250
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product number10303
Product descriptionCHIR99021 98%
Packaging25MG
Price$100
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product number10303
Product descriptionCHIR99021 98%
Packaging5MG
Price$35
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product numberSYN5163
Product descriptionCHIR 99021
Packaging50mg
Price$405
Updated2021-12-16
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ManufacturerAmbeed
Product numberA133052
Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
Packaging2mg
Price$31
Updated2021-12-16
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ManufacturerAmbeed
Product numberA133052
Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
Packaging25mg
Price$95
Updated2021-12-16
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ManufacturerAmbeed
Product numberA133052
Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
Packaging5mg
Price$54
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA133052
Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
Packaging10mg
Price$79
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA133052
Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
Packaging250mg
Price$206
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00382I	[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%	25mg	$28	2026-05-28	Buy
aablocks	AA00382I	[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%	50mg	$48	2026-05-28	Buy
aablocks	AA00382I	[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%	100mg	$72	2026-05-28	Buy
aablocks	AA00382I	[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%	250mg	$116	2026-05-28	Buy
aablocks	AA00382I	[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%	1g	$266	2026-05-28	Buy
aablocks	AA00382I	[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile 98%	5g	$840	2026-05-28	Buy
ACHEMBLOCK	10303	CHIR99021 98%	1G	$750	2026-05-27	Buy
ACHEMBLOCK	10303	CHIR99021 98%	100MG	$250	2026-05-27	Buy
ACHEMBLOCK	10303	CHIR99021 98%	25MG	$100	2026-05-27	Buy
ACHEMBLOCK	10303	CHIR99021 98%	5MG	$35	2026-05-27	Buy
AK Scientific	SYN5163	CHIR 99021	50mg	$405	2021-12-16	Buy
Ambeed	A133052	6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%	2mg	$31	2021-12-16	Buy
Ambeed	A133052	6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%	25mg	$95	2021-12-16	Buy
Ambeed	A133052	6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%	5mg	$54	2021-12-16	Buy
Ambeed	A133052	6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%	10mg	$79	2021-12-16	Buy
Ambeed	A133052	6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%	250mg	$206	2021-12-16	Buy

Next Last

Properties

Boiling point :784.1±70.0 °C(Predicted)
Density :1.48
storage temp. :-20°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :11.92±0.10(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :AQGNHMOJWBZFQQ-UHFFFAOYSA-N
SMILES :C1=NC(NCCNC2=NC=C(C3NC(C)=CN=3)C(C3=CC=C(Cl)C=C3Cl)=N2)=CC=C1C#N
CAS DataBase Reference :252917-06-9

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H300	Fatal if swallowed	Acute toxicity,oral	Category 1, 2	Danger	P264, P270, P301+P310, P321, P330,P405, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P301+P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a key inhibitory role in both the insulin and Wnt signaling pathways. CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.8 μM) and in isolated type 1 diabetic rat skeletal muscle. A single oral dose (30 mg/kg) of CHIR99021 enhances in vivo glucose metabolism in a rodent model of type 2 diabetes. CHIR99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.

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Suppliers and manufacturers

Anhui Ruihan Technology Co., Ltd

$30.00
CHIR-99021 CAS:252917-06-9

career henan chemical co

$2.00
6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile CAS:252917-06-9

TargetMol Chemicals Inc.

$36.00
CHIR-99021 CAS:252917-06-9

BOC Sciences

Capot Chemical Co.,Ltd.

ATK CHEMICAL COMPANY LIMITED

Biochempartner

CONIER CHEM AND PHARMA LIMITED

Shaanxi Dideu Medichem Co. Ltd

Chemia Biotechnology（Shanghai） Co., Ltd

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CHIR-99021

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Description

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