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ChemicalBook >> CAS DataBase List >> CYCLO(-PRO-VAL)

CYCLO(-PRO-VAL)

CYCLO(-PRO-VAL) price.
  • $37 - $207138
  • Product name: CYCLO(-PRO-VAL)
  • CAS: 2854-40-2
  • MF: C10H16N2O2
  • MW: 196.25
  • EINECS:
  • MDL Number:MFCD03093469
  • Synonyms:CYCLO(-PRO-VAL);(3S,8aS)-3-Isopropyl-6,7,8,8aα-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione;(3S,8aS)-3β-Isopropyl-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione;(3S,8aS)-Octahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aα)-3β-Isopropyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione;Cyclo(L-Pro-L-Val-);Cyclo(L-Val-L-Pro-);Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1-methylethyl)-, (3S,8aS)-
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • Arctom
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TCI Chemical
  • TRC
  • Usbiological
Package
  • 5MG
  • 10mg
  • 25mg
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  • 100mg
  • 250mg
  • 1G
  • 5g
  • Manufactureraablocks
  • Product numberAA002VL4
  • Product description(3S,8aS)-Hexahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione ≥95%
  • Packaging25mg
  • Price$41
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002VL4
  • Product description(3S,8aS)-Hexahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione 97%
  • Packaging100mg
  • Price$73
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002VL4
  • Product description(3S,8aS)-Hexahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione 97%
  • Packaging250mg
  • Price$122
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberX217776
  • Product descriptionCyclo(L-Pro-L-Val) 98%
  • Packaging100MG
  • Price$105
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberX217776
  • Product descriptionCyclo(L-Pro-L-Val) 98%
  • Packaging1G
  • Price$540
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number4800CQ
  • Product descriptionCyclo(L-Pro-L-Val)
  • Packaging250mg
  • Price$413
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number2854402
  • Product description(3S,8AS)-3-isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Packaging1g
  • Price$460.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAAA0008669
  • Product descriptionCYCLO(-PRO-VAL) 95.00%
  • Packaging5MG
  • Price$503.82
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberBD-A615036
  • Product descriptionCyclo(L-Pro-L-Val) 97%
  • Packaging5g
  • Price$1559
  • Updated2026-05-25
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  • ManufacturerArctom
  • Product numberBD-A615036
  • Product descriptionCyclo(L-Pro-L-Val) 97%
  • Packaging5g
  • Price$1559
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberBD-A615036
  • Product descriptionCyclo(L-Pro-L-Val) 97%
  • Packaging250mg
  • Price$110
  • Updated2026-05-25
  • Buy
  • ManufacturerArctom
  • Product numberBD-A615036
  • Product descriptionCyclo(L-Pro-L-Val) 97%
  • Packaging250mg
  • Price$110
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberBD-A615036
  • Product descriptionCyclo(L-Pro-L-Val) 97%
  • Packaging100mg
  • Price$65
  • Updated2026-05-25
  • Buy
  • ManufacturerArctom
  • Product numberBD-A615036
  • Product descriptionCyclo(L-Pro-L-Val) 97%
  • Packaging100mg
  • Price$65
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberBD-A615036
  • Product descriptionCyclo(L-Pro-L-Val) 97%
  • Packaging1g
  • Price$341
  • Updated2026-05-25
  • Buy
  • ManufacturerArctom
  • Product numberBD-A615036
  • Product descriptionCyclo(L-Pro-L-Val) 97%
  • Packaging1g
  • Price$341
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA002VL4 (3S,8aS)-Hexahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione ≥95% 25mg $41 2026-05-28 Buy
aablocks AA002VL4 (3S,8aS)-Hexahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione 97% 100mg $73 2026-05-28 Buy
aablocks AA002VL4 (3S,8aS)-Hexahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione 97% 250mg $122 2026-05-28 Buy
ACHEMBLOCK X217776 Cyclo(L-Pro-L-Val) 98% 100MG $105 2026-05-27 Buy
ACHEMBLOCK X217776 Cyclo(L-Pro-L-Val) 98% 1G $540 2026-05-27 Buy
AK Scientific 4800CQ Cyclo(L-Pro-L-Val) 250mg $413 2021-12-16 Buy
Alichem 2854402 (3S,8AS)-3-isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione 1g $460.6 2021-12-16 Buy
American Custom Chemicals Corporation AAA0008669 CYCLO(-PRO-VAL) 95.00% 5MG $503.82 2021-12-16 Buy
Arctom BD-A615036 Cyclo(L-Pro-L-Val) 97% 5g $1559 2026-05-25 Buy
Arctom BD-A615036 Cyclo(L-Pro-L-Val) 97% 5g $1559 2026-05-26 Buy
Arctom BD-A615036 Cyclo(L-Pro-L-Val) 97% 250mg $110 2026-05-25 Buy
Arctom BD-A615036 Cyclo(L-Pro-L-Val) 97% 250mg $110 2026-05-26 Buy
Arctom BD-A615036 Cyclo(L-Pro-L-Val) 97% 100mg $65 2026-05-25 Buy
Arctom BD-A615036 Cyclo(L-Pro-L-Val) 97% 100mg $65 2026-05-26 Buy
Arctom BD-A615036 Cyclo(L-Pro-L-Val) 97% 1g $341 2026-05-25 Buy
Arctom BD-A615036 Cyclo(L-Pro-L-Val) 97% 1g $341 2026-05-26 Buy

Properties

Melting point :190-192 °C
Boiling point :420.7±34.0 °C(Predicted)
Density :1.17±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :Chloroform (Slightly, Sonicated), Methanol (Slightly)
form :Solid
pka :13.15±0.40(Predicted)
color :White to Off-White
Sequence :Cyclo(Pro-Val)

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others. It is active against the bacteria S. aureus and B. subtilis (MICs = 16.3 and 18.2 μg/ml, respectively) but not E. coli (MIC = >20 μg/ml). Cyclo(L-Pro-L-Val) inhibits activation of a LuxR-dependent E. coli biosensor by the quorum-sensing molecule 3-oxo-hexanoyl-homoserine lactone (IC50 = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026. However, it does not activate or inhibit lacZ-based reporter fusions in S. liquefaciens or A. tumefaciens.

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