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ChemicalBook >> CAS DataBase List >> GSK583

GSK583

GSK583 price.
  • $35 - $11260
  • Product name: GSK583
  • CAS: 1346547-00-9
  • MF: C20H19FN4O2S
  • MW: 398.45
  • EINECS:-0
  • MDL Number:MFCD30343846
  • Synonyms:GSK583;SK583;6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine;RIP2 kinase inhibitor 583;CS-2216;GSK583, >98%;GSK-583;GSK 583;4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-
67 prices
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  • 10mM*1mLinDMSO(Solution)
  • 10mM*1mLinDMSO
  • 5MG
  • 10mM*1mLinDMSO(Solid+Solvent)
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  • Manufactureraablocks
  • Product numberAA009CK9
  • Product description6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98%
  • Packaging1mg
  • Price$36
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA009CK9
  • Product description6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98%
  • Packaging2mg
  • Price$47
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA009CK9
  • Product description6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine ≥98%
  • Packaging10mg
  • Price$49
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA009CK9
  • Product description6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine ≥98%
  • Packaging25mg
  • Price$115
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA009CK9
  • Product description6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98%
  • Packaging1g
  • Price$2192
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA009CK9
  • Product description6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98%
  • Packaging250mg
  • Price$913
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA009CK9
  • Product description6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine ≥98%
  • Packaging100mg
  • Price$376
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA009CK9
  • Product description6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98%
  • Packaging50mg
  • Price$194
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberO33801
  • Product descriptionGSK583 98%
  • Packaging100MG
  • Price$275
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product numberO33801
  • Product descriptionGSK583 98%
  • Packaging100MG
  • Price$275
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberO33801
  • Product descriptionGSK583 98%
  • Packaging1G
  • Price$1105
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product numberO33801
  • Product descriptionGSK583 98%
  • Packaging1G
  • Price$1105
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberO33801
  • Product descriptionGSK583 98%
  • Packaging25MG
  • Price$95
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33801
  • Product descriptionGSK583 98%
  • Packaging25MG
  • Price$95
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33801
  • Product descriptionGSK583 98%
  • Packaging5MG
  • Price$35
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33801
  • Product descriptionGSK583 98%
  • Packaging5MG
  • Price$35
  • Updated2026-05-27
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009CK9 6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98% 1mg $36 2026-05-28 Buy
aablocks AA009CK9 6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98% 2mg $47 2026-05-28 Buy
aablocks AA009CK9 6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine ≥98% 10mg $49 2026-05-28 Buy
aablocks AA009CK9 6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine ≥98% 25mg $115 2026-05-28 Buy
aablocks AA009CK9 6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98% 1g $2192 2026-05-28 Buy
aablocks AA009CK9 6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98% 250mg $913 2026-05-28 Buy
aablocks AA009CK9 6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine ≥98% 100mg $376 2026-05-28 Buy
aablocks AA009CK9 6-?[(1,?1-?Dimethylethyl)?sulfonyl]?-?N-?(5-?fluoro-?1H-?indazol-?3-?yl)?-4-?quinolinamine 98% 50mg $194 2026-05-28 Buy
ACHEMBLOCK O33801 GSK583 98% 100MG $275 2026-05-25 Buy
ACHEMBLOCK O33801 GSK583 98% 100MG $275 2026-05-27 Buy
ACHEMBLOCK O33801 GSK583 98% 1G $1105 2026-05-25 Buy
ACHEMBLOCK O33801 GSK583 98% 1G $1105 2026-05-27 Buy
ACHEMBLOCK O33801 GSK583 98% 25MG $95 2026-05-25 Buy
ACHEMBLOCK O33801 GSK583 98% 25MG $95 2026-05-27 Buy
ACHEMBLOCK O33801 GSK583 98% 5MG $35 2026-05-25 Buy
ACHEMBLOCK O33801 GSK583 98% 5MG $35 2026-05-27 Buy

Properties

Boiling point :652.9±55.0 °C(Predicted)
Density :1.402±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to at least 25 mg/ml).
form :solid
pka :12.59±0.40(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI :InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChIKey :XLOGLWKOHPIJLV-UHFFFAOYSA-N
SMILES :N1C2C(=CC(S(C(C)(C)C)(=O)=O)=CC=2)C(NC2C3=C(NN=2)C=CC(F)=C3)=CC=1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50= 5 nM human and IC50= 2 nM rat.1It also potently inhibits isolated RIP3 kinase (IC50= 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2

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