Geldanamycin
|
- $14 - $3791
- Product name: Geldanamycin
- CAS: 30562-34-6
- MF: C29H40N2O9
- MW: 560.64
- EINECS:999-999-2
- MDL Number:MFCD00274570
- Synonyms:CP-122634;9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-Carbamate;NSC 212518;GELDANAMYCIN FROM STRE;GeldanaMycin, froM StreptoMyces hygroscopicus var geldanus;GeldanaMycin froM StreptoMyces hygroscopi;2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate;Geldanamycin [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
144 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Thermo Scientific Chemicals
- Tocris
- TRC
- Usbiological
Package
- 100.00mg
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- 2.5mg
- 10mM*1mLinDMSO(Solution)
- 250.00mg
- 1
- 500mg
- 1000mg
- 1.00g
- 1ml
- 10mM(in1mLDMSO)
- 100μg
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- 10mM(in 1mL DMSO)
- 250MG
- Manufactureraablocks
- Product numberAA0038RF
- Product descriptionGeldanamycin 95%
- Packaging1mg
- Price$15
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038RF
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging10mg
- Price$21
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038RF
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging50mg
- Price$79
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038RF
- Product descriptionGeldanamycin 95%
- Packaging100mg
- Price$114
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0038RF
- Product descriptionGeldanamycin 95%
- Packaging1g
- Price$1134
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX212226
- Product descriptionGeldanamycin 97%
- Packaging250MG
- Price$225
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX212226
- Product descriptionGeldanamycin 97%
- Packaging100MG
- Price$145
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-M001
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging1mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-M005
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-C100
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging100μg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-C100
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging100μg
- Price$20
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-C500
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging500μg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-C500
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging500μg
- Price$35
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-M005
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging5mg
- Price$120
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberV2064
- Product descriptionGeldanamycin
- Packaging250mg
- Price$441
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ53200
- Product descriptionGeldanamycin 97%
- Packaging250mg
- Price$340
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0038RF | Geldanamycin 95% | 1mg | $15 | 2026-05-28 | Buy |
| aablocks | AA0038RF | Geldanamycin ≥98%(HPLC) | 10mg | $21 | 2026-05-28 | Buy |
| aablocks | AA0038RF | Geldanamycin ≥98%(HPLC) | 50mg | $79 | 2026-05-28 | Buy |
| aablocks | AA0038RF | Geldanamycin 95% | 100mg | $114 | 2026-05-28 | Buy |
| aablocks | AA0038RF | Geldanamycin 95% | 1g | $1134 | 2026-05-28 | Buy |
| ACHEMBLOCK | X212226 | Geldanamycin 97% | 250MG | $225 | 2026-05-27 | Buy |
| ACHEMBLOCK | X212226 | Geldanamycin 97% | 100MG | $145 | 2026-05-27 | Buy |
| Adipogen Life Sciences | BVT-0196-M001 | Geldanamycin ≥98%(HPLC) | 1mg | $55 | 2026-05-06 | Buy |
| Adipogen Life Sciences | BVT-0196-M005 | Geldanamycin ≥98%(HPLC) | 5mg | $110 | 2021-12-16 | Buy |
| Adipogen Life Sciences | BVT-0196-C100 | Geldanamycin ≥98%(HPLC) | 100μg | $20 | 2021-12-16 | Buy |
| Adipogen Life Sciences | BVT-0196-C100 | Geldanamycin ≥98%(HPLC) | 100μg | $20 | 2026-05-06 | Buy |
| Adipogen Life Sciences | BVT-0196-C500 | Geldanamycin ≥98%(HPLC) | 500μg | $35 | 2021-12-16 | Buy |
| Adipogen Life Sciences | BVT-0196-C500 | Geldanamycin ≥98%(HPLC) | 500μg | $35 | 2026-05-06 | Buy |
| Adipogen Life Sciences | BVT-0196-M005 | Geldanamycin ≥98%(HPLC) | 5mg | $120 | 2026-05-06 | Buy |
| AK Scientific | V2064 | Geldanamycin | 250mg | $441 | 2021-12-16 | Buy |
| AK Scientific | J53200 | Geldanamycin 97% | 250mg | $340 | 2026-06-04 | Buy |
Properties
Melting point :255 °C
Boiling point :627.87°C (rough estimate)
Density :1.2443 (rough estimate)
refractive index :1.5800 (estimate)
Flash point :87℃
storage temp. :-20°C
solubility :DMSO: soluble
form :powder
pka :8.42±0.70(Predicted)
color :yellow to orange
biological source :Streptomyces hygroscopicus
λmax :305nm(MeOH)(lit.)
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
InChIKey :QTQAWLPCGQOSGP-KSRBKZBZSA-N
SMILES :C1(OC)C(=O)C=C2NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)N)C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC=1C2=O |c:13,t:11,24|
CAS DataBase Reference :30562-34-6(CAS DataBase Reference)
Boiling point :627.87°C (rough estimate)
Density :1.2443 (rough estimate)
refractive index :1.5800 (estimate)
Flash point :87℃
storage temp. :-20°C
solubility :DMSO: soluble
form :powder
pka :8.42±0.70(Predicted)
color :yellow to orange
biological source :Streptomyces hygroscopicus
λmax :305nm(MeOH)(lit.)
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
InChIKey :QTQAWLPCGQOSGP-KSRBKZBZSA-N
SMILES :C1(OC)C(=O)C=C2NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)N)C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC=1C2=O |c:13,t:11,24|
CAS DataBase Reference :30562-34-6(CAS DataBase Reference)
Safety Information
| Symbol(GHS): |
 
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions. Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis. For example, geldanamycin inhibits c-jun expression in human colon adenocarcinoma HT29 cells (IC50 = 75 nM), inhibiting AP-1 binding. It also reduces signaling through mitogenic signaling proteins and interferes with steroid receptor function. Inhibitors of Hsp90, including geldanamycin, show promise in cancer therapy.Related product price
-
CHLOROPHOSPHONAZO III
$55-1925 -
p-Toluquinone
$5-2501.17 -
Telatinib
$18-8100
Suppliers and manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
Geldanamycin
CAS:30562-34-6
Shaanxi Xianhe Biotech Co., Ltd
Henan Tianfu Chemical Co.,Ltd.
BOC Sciences
SIMAGCHEM CORP
Geldanamycin
CAS:30562-34-6
