IPA-3
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- $29 - $1200
- Product name: IPA-3
- CAS: 42521-82-4
- MF: C20H14O2S2
- MW: 350.45
- EINECS:
- MDL Number:MFCD00388917
- Synonyms:1,1'-Dithiodi-2-naphthtol;IPA 3;p21-Activated Kinase Inhibitor III, IPA-3;Bis(2-hydroxy-1-naphthyl) disulfide;2-Naphthalenol, 1,1'-dithiobis-;1,1′-Disulfanediyldinaphthalen-2-ol;1,1'-Disulfanediylbis(naphthalen-2-ol);IPA 3;IPA3
64 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Thermo Scientific Chemicals
- Tocris
- TRC
- Usbiological
Package
- 50
- 10
- 1mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100MG
- 10mM*1mLinDMSO(Solid+Solvent)
- 250MG
- 1g
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA0071TD
- Product descriptionIPA-3 98%
- Packaging5mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071TD
- Product descriptionIPA-3 98%
- Packaging10mg
- Price$45
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0071TD
- Product descriptionIPA-3 98
- Packaging50mg
- Price$192
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228832
- Product descriptionIPA-3 97.00%
- Packaging25MG
- Price$140
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228832
- Product descriptionIPA-3 97.00%
- Packaging100MG
- Price$455
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228832
- Product descriptionIPA-3 97.00%
- Packaging250MG
- Price$910
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2478AH
- Product description1,1'-Dithiodi-2-naphthtol
- Packaging25mg
- Price$328
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA427173
- Product descriptionIPA-3 98+%
- Packaging10mg
- Price$69
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA427173
- Product descriptionIPA-3 98+%
- Packaging5mg
- Price$46
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2169
- Product descriptionIPA-3
- Packaging5mg
- Price$56
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB2169
- Product descriptionIPA-3
- Packaging10mg
- Price$78
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB2169
- Product descriptionIPA-3
- Packaging50mg
- Price$273
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2169
- Product descriptionIPA-3
- Packaging50mg
- Price$287
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-15663
- Product descriptionIPA-3 99.39%
- Packaging50mg
- Price$272
- Updated2026-05-25
- Buy
- ManufacturerArctom
- Product numberHY-15663
- Product descriptionIPA-3 99.39%
- Packaging50mg
- Price$272
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15663
- Product descriptionIPA-3 99.39%
- Packaging100mg
- Price$436
- Updated2026-05-25
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0071TD | IPA-3 98% | 5mg | $29 | 2026-05-28 | Buy |
| aablocks | AA0071TD | IPA-3 98% | 10mg | $45 | 2026-05-28 | Buy |
| aablocks | AA0071TD | IPA-3 98 | 50mg | $192 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228832 | IPA-3 97.00% | 25MG | $140 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228832 | IPA-3 97.00% | 100MG | $455 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228832 | IPA-3 97.00% | 250MG | $910 | 2026-05-27 | Buy |
| AK Scientific | 2478AH | 1,1'-Dithiodi-2-naphthtol | 25mg | $328 | 2021-12-16 | Buy |
| Ambeed | A427173 | IPA-3 98+% | 10mg | $69 | 2021-12-16 | Buy |
| Ambeed | A427173 | IPA-3 98+% | 5mg | $46 | 2021-12-16 | Buy |
| ApexBio Technology | B2169 | IPA-3 | 5mg | $56 | 2026-05-06 | Buy |
| ApexBio Technology | B2169 | IPA-3 | 10mg | $78 | 2026-05-06 | Buy |
| ApexBio Technology | B2169 | IPA-3 | 50mg | $273 | 2021-12-16 | Buy |
| ApexBio Technology | B2169 | IPA-3 | 50mg | $287 | 2026-05-06 | Buy |
| Arctom | HY-15663 | IPA-3 99.39% | 50mg | $272 | 2026-05-25 | Buy |
| Arctom | HY-15663 | IPA-3 99.39% | 50mg | $272 | 2026-05-26 | Buy |
| Arctom | HY-15663 | IPA-3 99.39% | 100mg | $436 | 2026-05-25 | Buy |
Properties
Melting point :172℃
Boiling point :543.7±35.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
pka :7.52±0.50(Predicted)
form :Yellow solid
color :off-white to yellow
Water Solubility :Soluble in DMSO or ethanol. Insoluble in water.
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
InChIKey :RFAXLXKIAKIUDT-UHFFFAOYSA-N
SMILES :Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34
CAS DataBase Reference :42521-82-4
Boiling point :543.7±35.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
pka :7.52±0.50(Predicted)
form :Yellow solid
color :off-white to yellow
Water Solubility :Soluble in DMSO or ethanol. Insoluble in water.
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
InChIKey :RFAXLXKIAKIUDT-UHFFFAOYSA-N
SMILES :Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34
CAS DataBase Reference :42521-82-4
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
p21-activated kinase 1 (PAK1) is a member of a family non-receptor serine/threonine kinases that are vital to normal cell function. Binding of various upstream partners to PAK1 results in release of an autoinhibitory domain that blocks activity of the kinase domain. PAK1 expression and activity is upregulated in several human cancers and is a potential therapeutic target for cancer intervention. IPA-3 is a cell-permeable allosteric inhibitor of PAK1 that is non-competitive with respect to ATP binding (IC50 = 2.5 μM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42.More related product prices
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