ISRIB
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- $54 - $2395.3
- Product name: ISRIB
- CAS: 548470-11-7
- MF: C22H24Cl2N2O4
- MW: 451.34
- EINECS:231-545-4
- MDL Number:MFCD27952932
- Synonyms:ISRIB;N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE);ISRIB N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE);Integrated Stress Response inhibitor;trans-N,N′-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)-acetamide;2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide;N,N'-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide];
2-(4-chlorophenoxy)-N-(4-{[(4-chlorophenoxy)acetyl]amino}cyclohexyl)acetami de
51 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
Package
- 5mg
- 10mg
- 0.025g
- 25mg
- 50mg
- 0.05g
- 0.1g
- 100MG
- 0.25g
- 250mg
- 0.5g
- 1G
- 1000mg
- 5G
- Manufactureraablocks
- Product numberAA00DIJG
- Product descriptionISRIB
- Packaging5mg
- Price$59
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DIJG
- Product descriptionISRIB
- Packaging10mg
- Price$83
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DIJG
- Product descriptionISRIB
- Packaging25mg
- Price$146
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DIJG
- Product descriptionISRIB
- Packaging50mg
- Price$232
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33713
- Product descriptionISRIB 98%
- Packaging1G
- Price$495
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33713
- Product descriptionISRIB 98%
- Packaging25MG
- Price$59
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33713
- Product descriptionISRIB 98%
- Packaging100MG
- Price$167
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33713
- Product descriptionISRIB 98%
- Packaging5G
- Price$1305
- Updated2026-05-27
- Buy
- ManufacturerApexBio Technology
- Product numberB6093
- Product descriptionISRIB
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6093
- Product descriptionISRIB
- Packaging5mg
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6093
- Product descriptionISRIB
- Packaging25mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6093
- Product descriptionISRIB
- Packaging25mg
- Price$235
- Updated2026-05-06
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2278
- Product descriptionISRIB
- Packaging50mg
- Price$374
- Updated2026-05-19
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2278
- Product descriptionISRIB
- Packaging10mg
- Price$104.5
- Updated2026-05-19
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545921
- Product descriptionISRIb >98%
- Packaging25mg
- Price$455.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545921
- Product descriptionISRIb >98%
- Packaging5mg
- Price$173.4
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00DIJG | ISRIB | 5mg | $59 | 2026-05-28 | Buy |
| aablocks | AA00DIJG | ISRIB | 10mg | $83 | 2026-05-28 | Buy |
| aablocks | AA00DIJG | ISRIB | 25mg | $146 | 2026-05-28 | Buy |
| aablocks | AA00DIJG | ISRIB | 50mg | $232 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33713 | ISRIB 98% | 1G | $495 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33713 | ISRIB 98% | 25MG | $59 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33713 | ISRIB 98% | 100MG | $167 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33713 | ISRIB 98% | 5G | $1305 | 2026-05-27 | Buy |
| ApexBio Technology | B6093 | ISRIB | 5mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | B6093 | ISRIB | 5mg | $60 | 2026-05-06 | Buy |
| ApexBio Technology | B6093 | ISRIB | 25mg | $235 | 2021-12-16 | Buy |
| ApexBio Technology | B6093 | ISRIB | 25mg | $235 | 2026-05-06 | Buy |
| Axon Medchem | Axon2278 | ISRIB | 50mg | $374 | 2026-05-19 | Buy |
| Axon Medchem | Axon2278 | ISRIB | 10mg | $104.5 | 2026-05-19 | Buy |
| Biorbyt Ltd | orb545921 | ISRIb >98% | 25mg | $455.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545921 | ISRIb >98% | 5mg | $173.4 | 2021-12-16 | Buy |
Properties
Melting point :270-273°C
Boiling point :719.0±60.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble1mg/mL, clear (warmed)
pka :13.63±0.40(Predicted)
form :powder
color :white to beige
InChIKey :HJGMCDHQPXTGAV-UHFFFAOYSA-N
SMILES :C1(NC(=O)COC2=CC=C(Cl)C=C2)CCC(NC(=O)COC2=CC=C(Cl)C=C2)CC1
Boiling point :719.0±60.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble1mg/mL, clear (warmed)
pka :13.63±0.40(Predicted)
form :powder
color :white to beige
InChIKey :HJGMCDHQPXTGAV-UHFFFAOYSA-N
SMILES :C1(NC(=O)COC2=CC=C(Cl)C=C2)CCC(NC(=O)COC2=CC=C(Cl)C=C2)CC1
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||
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Description
ISRIB (integrated stress response inhibitor) is an experimental drug that reverses the effects of eIF2α phosphorylation with an IC50 of 5 nM. It was discovered in the laboratory of Peter Walter at University of California, San Francisco (UCSF) through a semi-automated screening of a large library of small molecules by Carmela Sidrauski, who decided to pursue research on it. It has been shown to inhibit eIF2α phosphorylation-induced stress granule (SG) formation. Since eIF2α phosphorylation is known to be involved in memory formation, ISRIB was tested to see whether it would be active in vivo, and was found to readily cross the blood-brain barrier, with a half-life of eight hours.More related product prices
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ISRIB
CAS:548470-11-7