Nutlin-3b
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- $31 - $2928
- Product name: Nutlin-3b
- CAS: 675576-97-3
- MF: C30H30Cl2N4O4
- MW: 581.49
- EINECS:
- MDL Number:MFCD11977784
- Synonyms:Nutlin-3b;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone;2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3b;NUTLIN-3B;NUTLIN 3B;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid;CS-986;4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
62 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Synthonix
- TRC
- Usbiological
Package
- 2mg
- 5mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 2x5mg
- 10mM*1mLinDMSO(Solution)
- 10mg
- 25mg
- 50mg
- 100MG
- 250MG
- 1g
- Manufactureraablocks
- Product numberAA00FBGI
- Product descriptionNutlin-3b
- Packaging10mg
- Price$87
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBGI
- Product descriptionNutlin-3b
- Packaging25mg
- Price$149
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBGI
- Product descriptionNutlin-3b
- Packaging50mg
- Price$235
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBGI
- Product descriptionNutlin-3b
- Packaging5mg
- Price$59
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBGI
- Product descriptionNutlin-3b
- Packaging2mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBGI
- Product descriptionNutlin-3b ≥98%
- Packaging1mg
- Price$31
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberV143525
- Product description4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98%
- Packaging10MG
- Price$100
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberV143525
- Product description4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98%
- Packaging250MG
- Price$920
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberV143525
- Product description4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98%
- Packaging100MG
- Price$460
- Updated2026-05-27
- Buy
- ManufacturerApexBio Technology
- Product numberA2005
- Product descriptionNutlin-3b
- Packaging10mg
- Price$210
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA2005
- Product descriptionNutlin-3b
- Packaging5mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2005
- Product descriptionNutlin-3b
- Packaging5mg
- Price$130
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA2005
- Product descriptionNutlin-3b
- Packaging50mg
- Price$760
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-15335
- Product descriptionNutlin-3b 98.78%
- Packaging5mg
- Price$95
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15335
- Product descriptionNutlin-3b 98.78%
- Packaging100mg
- Price$737
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15335
- Product descriptionNutlin-3b 98.78%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$116
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00FBGI | Nutlin-3b | 10mg | $87 | 2026-05-28 | Buy |
| aablocks | AA00FBGI | Nutlin-3b | 25mg | $149 | 2026-05-28 | Buy |
| aablocks | AA00FBGI | Nutlin-3b | 50mg | $235 | 2026-05-28 | Buy |
| aablocks | AA00FBGI | Nutlin-3b | 5mg | $59 | 2026-05-28 | Buy |
| aablocks | AA00FBGI | Nutlin-3b | 2mg | $44 | 2026-05-28 | Buy |
| aablocks | AA00FBGI | Nutlin-3b ≥98% | 1mg | $31 | 2026-05-28 | Buy |
| ACHEMBLOCK | V143525 | 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98% | 10MG | $100 | 2026-05-27 | Buy |
| ACHEMBLOCK | V143525 | 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98% | 250MG | $920 | 2026-05-27 | Buy |
| ACHEMBLOCK | V143525 | 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98% | 100MG | $460 | 2026-05-27 | Buy |
| ApexBio Technology | A2005 | Nutlin-3b | 10mg | $210 | 2026-05-06 | Buy |
| ApexBio Technology | A2005 | Nutlin-3b | 5mg | $130 | 2021-12-16 | Buy |
| ApexBio Technology | A2005 | Nutlin-3b | 5mg | $130 | 2026-05-06 | Buy |
| ApexBio Technology | A2005 | Nutlin-3b | 50mg | $760 | 2026-05-06 | Buy |
| Arctom | HY-15335 | Nutlin-3b 98.78% | 5mg | $95 | 2026-05-26 | Buy |
| Arctom | HY-15335 | Nutlin-3b 98.78% | 100mg | $737 | 2026-05-26 | Buy |
| Arctom | HY-15335 | Nutlin-3b 98.78% | 10mM*1mLinDMSO(Solid+Solvent) | $116 | 2026-05-26 | Buy |
Properties
Density :1.36
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO
form :crystalline solid
pka :14.35±0.20(Predicted)
color :Off-white to yellow
InChIKey :BDUHCSBCVGXTJM-IZLXSDGUSA-N
SMILES :N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]2C2=CC=C(Cl)C=C2)=O)CC1=O
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO
form :crystalline solid
pka :14.35±0.20(Predicted)
color :Off-white to yellow
InChIKey :BDUHCSBCVGXTJM-IZLXSDGUSA-N
SMILES :N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]2C2=CC=C(Cl)C=C2)=O)CC1=O
Safety Information
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| Signal word: | Danger | ||||||||||||||||||||||||||||
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Description
(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC50 value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells.Related product price
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