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ChemicalBook >> CAS DataBase List >> Onalespib

Onalespib

$33 - $2841
Product name: Onalespib
CAS: 912999-49-6
MF: C24H31N3O3
MW: 409.52
EINECS:
MDL Number:MFCD18633198
Synonyms:(2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)Methyl)isoindolin-2-yl)Methanone;4-({5-[(4-Methylpiperazin-1-yl)Methyl]-2,3-dihydro-1H-isoindol-2-yl}carbonyl)-6-(propan-2-yl)benzene-1,3-diol;[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone;Onalespib;Onalespib (AT13387);[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone AT13387;AT13387, >=98%;Onalespib Lactate

Price71 Properties Safety Information Description

71 prices

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Brand

aablocks
ACHEMBLOCK
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals

Package

200mg
500mg
10mM*1mLinDMSO(Solution)
10mM*1mLinDMSO(Solid+Solvent)
10mM*1mLinDMSO
2mg
10mM(1mLinDMSO)
10g
10mM(in1mLDMSO)
1mg
5mg
10mg
25mg
50mg
100mg
250mg
1g

Manufactureraablocks
Product numberAA00GTYA
Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%
Packaging25mg
Price$128
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00GTYA
Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%
Packaging50mg
Price$203
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00GTYA
Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%
Packaging100mg
Price$324
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00GTYA
Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%
Packaging5mg
Price$58
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00GTYA
Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone ≥98%
Packaging1mg
Price$49
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00GTYA
Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone ≥98%
Packaging250mg
Price$693
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberX212395
Product descriptionOnalespib (AT13387) 97%
Packaging100MG
Price$350
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberX212395
Product descriptionOnalespib (AT13387) 97%
Packaging50MG
Price$220
Updated2026-05-27
Buy

ManufacturerAmbeed
Product numberA389427
Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
Packaging100mg
Price$251
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA389427
Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
Packaging1mg
Price$33
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA389427
Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
Packaging5mg
Price$65
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA389427
Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
Packaging10mg
Price$85
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA389427
Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
Packaging25mg
Price$111
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA389427
Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
Packaging50mg
Price$144
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA389427
Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
Packaging250mg
Price$501
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA389427
Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
Packaging1g
Price$1503
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00GTYA	[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%	25mg	$128	2026-05-28	Buy
aablocks	AA00GTYA	[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%	50mg	$203	2026-05-28	Buy
aablocks	AA00GTYA	[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%	100mg	$324	2026-05-28	Buy
aablocks	AA00GTYA	[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%	5mg	$58	2026-05-28	Buy
aablocks	AA00GTYA	[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone ≥98%	1mg	$49	2026-05-28	Buy
aablocks	AA00GTYA	[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone ≥98%	250mg	$693	2026-05-28	Buy
ACHEMBLOCK	X212395	Onalespib (AT13387) 97%	100MG	$350	2026-05-27	Buy
ACHEMBLOCK	X212395	Onalespib (AT13387) 97%	50MG	$220	2026-05-27	Buy
Ambeed	A389427	(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%	100mg	$251	2021-12-16	Buy
Ambeed	A389427	(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%	1mg	$33	2021-12-16	Buy
Ambeed	A389427	(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%	5mg	$65	2021-12-16	Buy
Ambeed	A389427	(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%	10mg	$85	2021-12-16	Buy
Ambeed	A389427	(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%	25mg	$111	2021-12-16	Buy
Ambeed	A389427	(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%	50mg	$144	2021-12-16	Buy
Ambeed	A389427	(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%	250mg	$501	2021-12-16	Buy
Ambeed	A389427	(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%	1g	$1503	2021-12-16	Buy

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Properties

Boiling point :605.7±55.0 °C(Predicted)
Density :1.237
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥13.25 mg/mL in DMSO; ≥47.7 mg/mL in EtOH with ultrasonic
form :solid
pka :8.50±0.48(Predicted)
color :White to off-white
InChI :InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3
InChIKey :IFRGXKKQHBVPCQ-UHFFFAOYSA-N
SMILES :C(N1CC2=C(C1)C=CC(CN1CCN(C)CC1)=C2)(C1=CC(C(C)C)=C(O)C=C1O)=O

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Onalespib, also known as AT13387, is a selective inhibitor of Hsp90 (IC50 = 18 nM). It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo. Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models. It differs from other HSP90 inhibitors in its longer duration of target inhibition and its favorable toxicity profile in phase I studies in patients with refractory solid tumors.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

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Onalespib

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