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ChemicalBook >> CAS DataBase List >> PFI-1

PFI-1

PFI-1 price.
  • $12 - $2691.1
  • Product name: PFI-1
  • CAS: 1403764-72-6
  • MF: C16H17N3O4S
  • MW: 347.39
  • EINECS:
  • MDL Number:MFCD22580416
  • Synonyms:PFI-1;PFI-1 (PF-6405761);PFI-1 (PF-06405761);PF-06405761;Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-;2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide PFI-1 (PF-6405761);2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-bezenesulfonamide;PFI-1;PFI-1;PFI 1;PFI1
84 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • BroadPharm
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO
  • 100.00mg
  • 50.00mg
  • 10mM*1mLinDMSO(Solution)
  • 50
  • 200mg
  • 10
  • 250.00mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 1mg
  • 5mg
  • 10mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • Manufactureraablocks
  • Product numberAA009CBG
  • Product description2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98%
  • Packaging5mg
  • Price$23
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009CBG
  • Product description2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98%
  • Packaging10mg
  • Price$32
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009CBG
  • Product description2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98%
  • Packaging1mg
  • Price$12
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009CBG
  • Product description2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98%
  • Packaging50mg
  • Price$80
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009CBG
  • Product description2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98%
  • Packaging100mg
  • Price$122
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009CBG
  • Product description2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98%
  • Packaging250mg
  • Price$207
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10245
  • Product descriptionPFI-1 98%
  • Packaging100MG
  • Price$275
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10245
  • Product descriptionPFI-1 98%
  • Packaging1G
  • Price$870
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10245
  • Product descriptionPFI-1 98%
  • Packaging25MG
  • Price$105
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN3009
  • Product descriptionPF-06405761
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA280183
  • Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
  • Packaging1mg
  • Price$23
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA280183
  • Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
  • Packaging5mg
  • Price$47
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA280183
  • Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
  • Packaging10mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA280183
  • Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
  • Packaging250mg
  • Price$545
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA280183
  • Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
  • Packaging100mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA280183
  • Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
  • Packaging50mg
  • Price$185
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009CBG 2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98% 5mg $23 2026-05-28 Buy
aablocks AA009CBG 2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98% 10mg $32 2026-05-28 Buy
aablocks AA009CBG 2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98% 1mg $12 2026-05-28 Buy
aablocks AA009CBG 2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98% 50mg $80 2026-05-28 Buy
aablocks AA009CBG 2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98% 100mg $122 2026-05-28 Buy
aablocks AA009CBG 2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-yl)Benzenesulfonamide 98% 250mg $207 2026-05-28 Buy
ACHEMBLOCK 10245 PFI-1 98% 100MG $275 2026-05-27 Buy
ACHEMBLOCK 10245 PFI-1 98% 1G $870 2026-05-27 Buy
ACHEMBLOCK 10245 PFI-1 98% 25MG $105 2026-05-27 Buy
AK Scientific SYN3009 PF-06405761 10mg $175 2021-12-16 Buy
Ambeed A280183 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+% 1mg $23 2021-12-16 Buy
Ambeed A280183 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+% 5mg $47 2021-12-16 Buy
Ambeed A280183 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+% 10mg $67 2021-12-16 Buy
Ambeed A280183 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+% 250mg $545 2021-12-16 Buy
Ambeed A280183 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+% 100mg $260 2021-12-16 Buy
Ambeed A280183 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+% 50mg $185 2021-12-16 Buy

Properties

storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
color :white to beige
InChI :1S/C16H17N3O4S/c1-19-10-11-9-12(7-8-13(11)17-16(19)20)18-24(21,22)15-6-4-3-5-14(15)23-2/h3-9,18H,10H2,1-2H3,(H,17,20)
InChIKey :TXZPMHLMPKIUGK-UHFFFAOYSA-N
SMILES :COc1ccccc1S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Bromodomains recognize acetylated lysine residues and recruit regulatory complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The isolated individual or tandem bromodomains of bromodomain-containing protein (BRD) 2 and BRD4 bind acetylated histone tails, which couples histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of bromodomain interactions hold promise as useful therapeutics for human disease. PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. In an AlphaScreen assay it has been shown to inhibit BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC50 values of 98 nM and 0.22 μM, respectively. See the Structural Genomics Consortium (SGC) website for more information.

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