PLX5622
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- $18 - $1800
- Product name: PLX5622
- CAS: 1303420-67-8
- MF: C21H19F2N5O
- MW: 395.41
- EINECS:
- MDL Number:MFCD32201039
- Synonyms:PLX5622;PLX 5622;PLX-5622;3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-;5-Fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine;PLX5622 USP/EP/BP;6-FLUORO-N-((5-FLUORO-2-METHOXYPYRIDIN-3-YL)METHYL)-5-((5-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)METHYL)PYRIDIN-2-AMINE;PLX5622,PLX 5622,Inhibitor,CSF-1 receptor,microglial,CSF1R,orally,pathology,inhibit,c-Fms,penetrant,preceding,brain,colony stimulating factor 1 receptor,CSF-1R,elimination;6-Fluoro-N-[(5-fluoro-2-methoxy-3-pyridyl)methyl]-5-[(5-methyl-7-azaindole-3-yl)methyl]pyridin-2-amine
55 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 2mg
- 1mg
- 10mM*1mLinDMSO
- 10mM(1mLinDMSO)
- 5mg
- 10.00mg
- 10mg
- 25.00mg
- 25mg
- 50mg
- 50.00mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA01LIMY
- Product description6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98%
- Packaging1mg
- Price$18
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01LIMY
- Product description6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98%
- Packaging5mg
- Price$38
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01LIMY
- Product description6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98%
- Packaging10mg
- Price$56
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01LIMY
- Product description6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98%
- Packaging25mg
- Price$95
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01LIMY
- Product description6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98%
- Packaging50mg
- Price$148
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01LIMY
- Product description6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98%
- Packaging100mg
- Price$233
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01LIMY
- Product description6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98%
- Packaging250mg
- Price$409
- Updated2026-05-30
- Buy
- ManufacturerAK Scientific
- Product number1283DJ
- Product descriptionCID52936034
- Packaging25mg
- Price$935
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB8575
- Product descriptionPLX-5622
- Packaging100mg
- Price$818
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8575
- Product descriptionPLX-5622
- Packaging25mg
- Price$345
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8575
- Product descriptionPLX-5622
- Packaging50mg
- Price$564
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC8694
- Product descriptionPLX5622 hemifumarate
- Packaging25mg
- Price$279
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8575
- Product descriptionPLX-5622
- Packaging10mg
- Price$173
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC8694
- Product descriptionPLX5622 hemifumarate
- Packaging10mg
- Price$183
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8575
- Product descriptionPLX-5622
- Packaging5mg
- Price$109
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC8694
- Product descriptionPLX5622 hemifumarate
- Packaging5mg
- Price$112
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01LIMY | 6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98% | 1mg | $18 | 2026-05-30 | Buy |
| aablocks | AA01LIMY | 6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98% | 5mg | $38 | 2026-05-30 | Buy |
| aablocks | AA01LIMY | 6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98% | 10mg | $56 | 2026-05-30 | Buy |
| aablocks | AA01LIMY | 6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98% | 25mg | $95 | 2026-05-30 | Buy |
| aablocks | AA01LIMY | 6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98% | 50mg | $148 | 2026-05-30 | Buy |
| aablocks | AA01LIMY | 6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98% | 100mg | $233 | 2026-05-30 | Buy |
| aablocks | AA01LIMY | 6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine 98% | 250mg | $409 | 2026-05-30 | Buy |
| AK Scientific | 1283DJ | CID52936034 | 25mg | $935 | 2021-12-16 | Buy |
| ApexBio Technology | B8575 | PLX-5622 | 100mg | $818 | 2026-05-06 | Buy |
| ApexBio Technology | B8575 | PLX-5622 | 25mg | $345 | 2026-05-06 | Buy |
| ApexBio Technology | B8575 | PLX-5622 | 50mg | $564 | 2026-05-06 | Buy |
| ApexBio Technology | C8694 | PLX5622 hemifumarate | 25mg | $279 | 2026-05-06 | Buy |
| ApexBio Technology | B8575 | PLX-5622 | 10mg | $173 | 2026-05-06 | Buy |
| ApexBio Technology | C8694 | PLX5622 hemifumarate | 10mg | $183 | 2026-05-06 | Buy |
| ApexBio Technology | B8575 | PLX-5622 | 5mg | $109 | 2026-05-06 | Buy |
| ApexBio Technology | C8694 | PLX5622 hemifumarate | 5mg | $112 | 2026-05-06 | Buy |
Properties
Density :1.364±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :13+-.0.40(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26)
InChIKey :NSMOZFXKTHCPTQ-UHFFFAOYSA-N
SMILES :C1(OC)=NC=C(F)C=C1CNC1=NC(F)=C(CC2C3=CC(C)=CN=C3NC=2)C=C1
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :13+-.0.40(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26)
InChIKey :NSMOZFXKTHCPTQ-UHFFFAOYSA-N
SMILES :C1(OC)=NC=C(F)C=C1CNC1=NC(F)=C(CC2C3=CC(C)=CN=C3NC=2)C=C1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
PLX5622 (1303420-67-8) is a highly selective (>20 fold over KIT and FLT3, >60 fold over 200 other kinases) and brain-penetrant inhibitor of colony-stimulating factor 1 receptor (CSF1R; IC50 = 16 nM).1 It prevented plaque formation in 5xFAD1 and 3xTg2 mouse models of Alzheimer’s disease via elimination of microglia in a CSF1R-dependent manner. PLX5622 showed efficacy in a mouse neuropathic pain model via reduction of CD86+ macrophages resulting in reduced expression of pro-inflammatory cytokines.3 It also was able to ameliorate peripheral neuropathy in aging mice.4 PLX5622 displayed neuroprotective effects during the chronic phase of a traumatic brain injury mouse model.5 PLX5622 has also been shown to affect myeloid and lymphoid compartments, indicating that its affects are not limited to microglia and include peripheral immune cells.6Related product price
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