PP1
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- $28 - $3987
- Product name: PP1
- CAS: 172889-26-8
- MF: C16H19N5
- MW: 281.36
- EINECS:
- MDL Number:MFCD01076570
- Synonyms:PP1 Base;EI 275;1-(1,1-Dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine;AGL 1872;4-AMINO-5-(4-METHYLPHENYL)-7-(T-BUTYL)PYRAZOLO[3,4-D]PYRIMIDINE;4-AMINO-5-(4-METHYLPHENYL)-7-(TERT-BUTYL)PYRAZOLO[3,4-D]PYRIMIDINE;1-(TERT-BUTYL)-3-(4-METHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
75 prices
Selected condition：
Brand
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
- Usbiological
Package
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- 100MG
- EvaluationSample
- 10mM*1mLinDMSO(Solution)
- 1.00mg
- 1unit
- 5.00mg
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10.00mg
- 10mM(in 1mL DMSO)
- 10mg
- 25mg
- 50mg
- 250MG
- 1g
- ManufacturerACHEMBLOCK
- Product numberX212439
- Product descriptionPP1 97%
- Packaging100MG
- Price$560
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX212439
- Product descriptionPP1 97%
- Packaging250MG
- Price$1120
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3562-M005
- Product descriptionPP1 ≥98%(HPLC)
- Packaging5mg
- Price$120
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3562-M001
- Product descriptionPP1 ≥98%(HPLC)
- Packaging1mg
- Price$45
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3562-M005
- Product descriptionPP1 ≥98%(HPLC)
- Packaging5mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number8912AA
- Product description1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Packaging100mg
- Price$744
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5653
- Product descriptionPP1
- Packaging50mg
- Price$547
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5653
- Product descriptionPP1
- Packaging100mg
- Price$931
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA211100
- Product descriptionPP1 95+%
- Packaging50mg
- Price$361
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA211100
- Product descriptionPP1 95+%
- Packaging100mg
- Price$469
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA211100
- Product descriptionPP1 95+%
- Packaging1g
- Price$3987
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA211100
- Product descriptionPP1 95+%
- Packaging5mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA211100
- Product descriptionPP1 95+%
- Packaging10mg
- Price$214
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8215
- Product descriptionPP1
- Packaging25mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8215
- Product descriptionPP1
- Packaging10mM(in 1mL DMSO)
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8215
- Product descriptionPP1
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | X212439 | PP1 97% | 100MG | $560 | 2026-05-27 | Buy |
| ACHEMBLOCK | X212439 | PP1 97% | 250MG | $1120 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3562-M005 | PP1 ≥98%(HPLC) | 5mg | $120 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3562-M001 | PP1 ≥98%(HPLC) | 1mg | $45 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3562-M005 | PP1 ≥98%(HPLC) | 5mg | $130 | 2021-12-16 | Buy |
| AK Scientific | 8912AA | 1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 100mg | $744 | 2021-12-16 | Buy |
| AK Scientific | SYN5653 | PP1 | 50mg | $547 | 2021-12-16 | Buy |
| AK Scientific | SYN5653 | PP1 | 100mg | $931 | 2021-12-16 | Buy |
| Ambeed | A211100 | PP1 95+% | 50mg | $361 | 2021-12-16 | Buy |
| Ambeed | A211100 | PP1 95+% | 100mg | $469 | 2021-12-16 | Buy |
| Ambeed | A211100 | PP1 95+% | 1g | $3987 | 2021-12-16 | Buy |
| Ambeed | A211100 | PP1 95+% | 5mg | $165 | 2021-12-16 | Buy |
| Ambeed | A211100 | PP1 95+% | 10mg | $214 | 2021-12-16 | Buy |
| ApexBio Technology | A8215 | PP1 | 25mg | $250 | 2021-12-16 | Buy |
| ApexBio Technology | A8215 | PP1 | 10mM(in 1mL DMSO) | $132 | 2021-12-16 | Buy |
| ApexBio Technology | A8215 | PP1 | 10mg | $110 | 2021-12-16 | Buy |
Properties
Melting point :205-207°C
storage temp. :room temp
solubility :DMSO: >20mg/mL
form :powder
color :white to off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChI :1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChIKey :ZVPDNRVYHLRXLX-UHFFFAOYSA-N
SMILES :Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
storage temp. :room temp
solubility :DMSO: >20mg/mL
form :powder
color :white to off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChI :1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChIKey :ZVPDNRVYHLRXLX-UHFFFAOYSA-N
SMILES :Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. PP1 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM), and Src (IC50 = 170 nM) without significantly affecting the activity of EGFR kinase (IC50 = 250 nM), JAK2 (IC50 = 50 μM), or ZAP-70 (IC50 ≥ 0.6 μM). PP1 inhibits anti-CD3-induced tyrosine phosphorylation of human T cells with an IC50 value of 600 nM. It exhibits antitumor activity by antagonizing both proliferation and the inhibition of apoptosis mediated by a stem cell factor/mast cell growth factor in hematopoietic and small cell lung cancer cell lines. PP1 also blocks TGF-β-mediated cellular responses by directly inhibiting type I TGF-β receptors (IC50 = 50 nM) in a manner unrelated to Src signaling.Related product price
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