SGC-GAK-1
|
- $41 - $4023.9
- Product name: SGC-GAK-1
- CAS: 2226517-76-4
- MF: C18H17BrN2O3
- MW: 389.24
- EINECS:
- MDL Number:MFCD31689258
- Synonyms:SGC-GAK-1;GAK INHIBITOR 1;6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine;4-Quinolinamine, 6-bromo-N-(3,4,5-trimethoxyphenyl)-;6-Bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine;SGCGAK1,Inhibitor,SGC GAK 1,inhibit;S C- AK-1;SGC-GAK-1, 10 mM in DMSO
54 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- Apolloscientific
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5mg
- 10mg
- 5
- 1mg
- 25
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- 5G
- Manufactureraablocks
- Product numberAA01ENEM
- Product descriptionSGC GAK 1 98
- Packaging10mg
- Price$79
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENEM
- Product descriptionSGC GAK 1 98
- Packaging25mg
- Price$139
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENEM
- Product descriptionSGC GAK 1 98
- Packaging50mg
- Price$211
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENEM
- Product descriptionSGC GAK 1 98
- Packaging100mg
- Price$303
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENEM
- Product descriptionSGC GAK 1 98%
- Packaging5mg
- Price$53
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENEM
- Product descriptionSGC GAK 1 98%
- Packaging1mg
- Price$44
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberS86769
- Product descriptionSGC-GAK-1 98%
- Packaging5G
- Price$3580
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS86769
- Product descriptionSGC-GAK-1 98%
- Packaging5G
- Price$3580
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS86769
- Product descriptionSGC-GAK-1 98%
- Packaging1G
- Price$895
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS86769
- Product descriptionSGC-GAK-1 98%
- Packaging1G
- Price$895
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS86769
- Product descriptionSGC-GAK-1 98%
- Packaging100MG
- Price$180
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS86769
- Product descriptionSGC-GAK-1 98%
- Packaging100MG
- Price$180
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number8008EL
- Product descriptionSgc-gak-1
- Packaging5mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1142890
- Product description6-Bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine 98%
- Packaging10mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1142890
- Product description6-Bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine 98%
- Packaging5mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0080
- Product descriptionSGC-GAK-1 98%
- Packaging1mg
- Price$69
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01ENEM | SGC GAK 1 98 | 10mg | $79 | 2026-05-30 | Buy |
| aablocks | AA01ENEM | SGC GAK 1 98 | 25mg | $139 | 2026-05-30 | Buy |
| aablocks | AA01ENEM | SGC GAK 1 98 | 50mg | $211 | 2026-05-30 | Buy |
| aablocks | AA01ENEM | SGC GAK 1 98 | 100mg | $303 | 2026-05-30 | Buy |
| aablocks | AA01ENEM | SGC GAK 1 98% | 5mg | $53 | 2026-05-30 | Buy |
| aablocks | AA01ENEM | SGC GAK 1 98% | 1mg | $44 | 2026-05-30 | Buy |
| ACHEMBLOCK | S86769 | SGC-GAK-1 98% | 5G | $3580 | 2026-05-25 | Buy |
| ACHEMBLOCK | S86769 | SGC-GAK-1 98% | 5G | $3580 | 2026-05-27 | Buy |
| ACHEMBLOCK | S86769 | SGC-GAK-1 98% | 1G | $895 | 2026-05-25 | Buy |
| ACHEMBLOCK | S86769 | SGC-GAK-1 98% | 1G | $895 | 2026-05-27 | Buy |
| ACHEMBLOCK | S86769 | SGC-GAK-1 98% | 100MG | $180 | 2026-05-25 | Buy |
| ACHEMBLOCK | S86769 | SGC-GAK-1 98% | 100MG | $180 | 2026-05-27 | Buy |
| AK Scientific | 8008EL | Sgc-gak-1 | 5mg | $170 | 2021-12-16 | Buy |
| Ambeed | A1142890 | 6-Bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine 98% | 10mg | $420 | 2021-12-16 | Buy |
| Ambeed | A1142890 | 6-Bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine 98% | 5mg | $420 | 2021-12-16 | Buy |
| Apolloscientific | BISN0080 | SGC-GAK-1 98% | 1mg | $69 | 2026-06-04 | Buy |
Properties
Boiling point :484.9±45.0 °C(Predicted)
Density :1.436±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
form :powder
pka :6.43±0.49(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C18H17BrN2O3/c1-22-16-9-12(10-17(23-2)18(16)24-3)21-15-6-7-20-14-5-4-11(19)8-13(14)15/h4-10H,1-3H3,(H,20,21)
InChIKey :AUOSKLDNVNGKRR-UHFFFAOYSA-N
SMILES :BrC1=CC2=C(NC3=CC(OC)=C(OC)C(OC)=C3)C=CN=C2C=C1
Density :1.436±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
form :powder
pka :6.43±0.49(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C18H17BrN2O3/c1-22-16-9-12(10-17(23-2)18(16)24-3)21-15-6-7-20-14-5-4-11(19)8-13(14)15/h4-10H,1-3H3,(H,20,21)
InChIKey :AUOSKLDNVNGKRR-UHFFFAOYSA-N
SMILES :BrC1=CC2=C(NC3=CC(OC)=C(OC)C(OC)=C3)C=CN=C2C=C1
Safety Information
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Description
SGC-GAK-1 (2226517-76-4) is a highly potent and selective inhibitor of cyclin G associated kinase (GAK), a member of the numb-associated kinase (NAK) family involved in membrane trafficking and sorting of proteins and is required for the maintenance of centrosome maturation and progression though mitosis. KD= 1.9 nM with >50-fold selectivity against a panel of 400 kinases. It also displayed affinity for RIPK2 (KD= 110 nM) and ADCK3 (KD= 190 nM). SGC-GAK-1 displayed potent cellular activity in HEK293T cells (IC50= 120 nM) and showed strong growth inhibition in the prostate cancer cell lines LNCaP (IC50= 0.65 μM) and 22Rv1 (IC50= 0.17 μM).Related product price
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