Trilostane
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- $39 - $1593.9
- Product name: Trilostane
- CAS: 13647-35-3
- MF: C20H27NO3
- MW: 329.43
- EINECS:237-133-0
- MDL Number:MFCD00199295
- Synonyms:TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car ;17-beta)-ph ;(4a,5a,17b)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile;5a-Androstane-2a-carbonitrile, 4a,5-epoxy-17b-hydroxy-3-oxo-;Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)-;4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile;4α,5-Epoxy-3,17β-dihydroxy-5α-androstan-2-ene-2-carbonitrile
55 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AHH
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 10mM(in1mLDMSO)
- 5mg
- 25mg
- 250mg
- 10g
- 50g
- 250g
- 500g
- 10mM(in 1mL DMSO)
- 10mg
- 50mg
- 100mg
- 200MG
- 500mg
- 1g
- 5g
- 25G
- Manufactureraablocks
- Product numberAA0011TS
- Product descriptionTrilostane ≥98%
- Packaging250mg
- Price$90
- Updated2026-05-27
- Buy
- Manufactureraablocks
- Product numberAA0011TS
- Product descriptionTrilostane
- Packaging500mg
- Price$171
- Updated2026-05-27
- Buy
- Manufactureraablocks
- Product numberAA0011TS
- Product descriptionTrilostane ≥98%
- Packaging1g
- Price$239
- Updated2026-05-27
- Buy
- Manufactureraablocks
- Product numberAA0011TS
- Product descriptionTrilostane ≥98%
- Packaging5g
- Price$952
- Updated2026-05-27
- Buy
- Manufactureraablocks
- Product numberAA0011TS
- Product descriptionTrilostane ≥98%
- Packaging100mg
- Price$46
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10527
- Product descriptionTrilostane 98%
- Packaging25G
- Price$950
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10527
- Product descriptionTrilostane 98%
- Packaging25G
- Price$950
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10527
- Product descriptionTrilostane 98%
- Packaging5G
- Price$280
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10527
- Product descriptionTrilostane 98%
- Packaging5G
- Price$280
- Updated2026-05-25
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-T0449-M050
- Product descriptionTrilostane ≥98%(HPLC)
- Packaging50mg
- Price$264
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-T0449-M010
- Product descriptionTrilostane ≥98%(HPLC)
- Packaging10mg
- Price$66
- Updated2026-05-06
- Buy
- ManufacturerAHH
- Product numberMT-59927
- Product descriptionTrilostane 99%
- Packaging1g
- Price$630
- Updated2021-12-16
- Buy
- ManufacturerAHH
- Product numberMT-59927
- Product descriptionTrilostane 97%
- Packaging1g
- Price$630
- Updated2026-05-25
- Buy
- ManufacturerAHH
- Product numberMT-59927
- Product descriptionTrilostane 97%
- Packaging1g
- Price$630
- Updated2026-05-26
- Buy
- ManufacturerAK Scientific
- Product numberJ40158
- Product descriptionTrilostane
- Packaging50mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ11209
- Product descriptionTrilostane
- Packaging10mg
- Price$49
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0011TS | Trilostane ≥98% | 250mg | $90 | 2026-05-27 | Buy |
| aablocks | AA0011TS | Trilostane | 500mg | $171 | 2026-05-27 | Buy |
| aablocks | AA0011TS | Trilostane ≥98% | 1g | $239 | 2026-05-27 | Buy |
| aablocks | AA0011TS | Trilostane ≥98% | 5g | $952 | 2026-05-27 | Buy |
| aablocks | AA0011TS | Trilostane ≥98% | 100mg | $46 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10527 | Trilostane 98% | 25G | $950 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10527 | Trilostane 98% | 25G | $950 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10527 | Trilostane 98% | 5G | $280 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10527 | Trilostane 98% | 5G | $280 | 2026-05-25 | Buy |
| Adipogen Life Sciences | CDX-T0449-M050 | Trilostane ≥98%(HPLC) | 50mg | $264 | 2026-05-06 | Buy |
| Adipogen Life Sciences | CDX-T0449-M010 | Trilostane ≥98%(HPLC) | 10mg | $66 | 2026-05-06 | Buy |
| AHH | MT-59927 | Trilostane 99% | 1g | $630 | 2021-12-16 | Buy |
| AHH | MT-59927 | Trilostane 97% | 1g | $630 | 2026-05-25 | Buy |
| AHH | MT-59927 | Trilostane 97% | 1g | $630 | 2026-05-26 | Buy |
| AK Scientific | J40158 | Trilostane | 50mg | $95 | 2021-12-16 | Buy |
| AK Scientific | J11209 | Trilostane | 10mg | $49 | 2021-12-16 | Buy |
Properties
Melting point :264 °C
alpha :D25 +137.4° (c = 1 in pyridine)
Boiling point :467.02°C (rough estimate)
Density :1.1213 (rough estimate)
refractive index :1.5614 (estimate)
storage temp. :2-8°C
solubility :DMSO: ≥17mg/mL
form :powder
pka :8.57±0.70(Predicted)
color :white to tan
InChI :1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
InChIKey :KVJXBPDAXMEYOA-CXANFOAXSA-N
SMILES :[C@@]123CC[C@@]4([H])[C@]5([H])CC[C@H](O)[C@@]5(C)CC[C@]4([H])[C@@]1(C)CC(C#N)=C(O)[C@@]2([H])O3 |&1:0,3,5,9,11,15,17,25,r|
CAS DataBase Reference :13647-35-3(CAS DataBase Reference)
EPA Substance Registry System :Trilostane (13647-35-3)
alpha :D25 +137.4° (c = 1 in pyridine)
Boiling point :467.02°C (rough estimate)
Density :1.1213 (rough estimate)
refractive index :1.5614 (estimate)
storage temp. :2-8°C
solubility :DMSO: ≥17mg/mL
form :powder
pka :8.57±0.70(Predicted)
color :white to tan
InChI :1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
InChIKey :KVJXBPDAXMEYOA-CXANFOAXSA-N
SMILES :[C@@]123CC[C@@]4([H])[C@]5([H])CC[C@H](O)[C@@]5(C)CC[C@]4([H])[C@@]1(C)CC(C#N)=C(O)[C@@]2([H])O3 |&1:0,3,5,9,11,15,17,25,r|
CAS DataBase Reference :13647-35-3(CAS DataBase Reference)
EPA Substance Registry System :Trilostane (13647-35-3)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
3β-hydroxysteroid dehydrogenase (3β-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3β-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3β-HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 with Ki values of 0.10 and 1.60 μM, respectively. Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels. Because human 3β-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.Related product price
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Suppliers and manufacturers
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