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ChemicalBook >> CAS DataBase List >> Vardenafil

Vardenafil

Vardenafil price.
  • $12 - $1880
  • Product name: Vardenafil
  • CAS: 224785-90-4
  • MF: C23H32N6O4S
  • MW: 488.6
  • EINECS:607-088-5
  • MDL Number:MFCD07773094
  • Synonyms:VARDENAFIL(SUBJECTTOPATENTFREE);VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE);2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one;1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine hydrochloride trihydrate;2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one;2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one;Methanol (test Vardenafil diHCl, 1.0 mg/mL as free base);Vardenafil (Vivanza)
39 prices
Selected condition:
Brand
  • aablocks
  • AHH
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Cayman Chemical
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
Package
  • 10mM*1mLinDMSO(Solution)
  • 25mg
  • 50mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 5mg
  • 250.00mg
  • EvaluationSample
  • 1.00g
  • 1mL
  • 5.00g
  • 1mg
  • 10mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • 10g
  • 10mM(in1mLDMSO)
  • 5g
  • 25g
  • Manufactureraablocks
  • Product numberAA00I4D1
  • Product description2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 98%
  • Packaging250mg
  • Price$30
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00I4D1
  • Product description2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 97%
  • Packaging1g
  • Price$33
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00I4D1
  • Product description2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 98%
  • Packaging1mg
  • Price$12
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00I4D1
  • Product description2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one ≥99%
  • Packaging200mg
  • Price$24
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00I4D1
  • Product description2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 97%
  • Packaging5g
  • Price$90
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00I4D1
  • Product description2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 97%
  • Packaging10g
  • Price$157
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00I4D1
  • Product description2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 97%
  • Packaging25g
  • Price$274
  • Updated2026-05-29
  • Buy
  • ManufacturerAHH
  • Product numberMT-60344
  • Product descriptionVardenafil 98%
  • Packaging5g
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberMT-60344
  • Product descriptionVardenafil 97%
  • Packaging5g
  • Price$270
  • Updated2026-05-25
  • Buy
  • ManufacturerAHH
  • Product numberMT-60344
  • Product descriptionVardenafil 97%
  • Packaging5g
  • Price$270
  • Updated2026-05-26
  • Buy
  • ManufacturerAK Scientific
  • Product numberE429
  • Product descriptionVardenafil
  • Packaging10mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008769
  • Product descriptionVARDENAFIL 95.00%
  • Packaging10MG
  • Price$255.15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008769
  • Product descriptionVARDENAFIL 95.00%
  • Packaging1G
  • Price$722.8
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3343
  • Product descriptionVardenafil
  • Packaging100mg
  • Price$92
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3343
  • Product descriptionVardenafil
  • Packaging10mg
  • Price$55
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3343
  • Product descriptionVardenafil
  • Packaging10mM(in1mLDMSO)
  • Price$61
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00I4D1 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 98% 250mg $30 2026-05-29 Buy
aablocks AA00I4D1 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 97% 1g $33 2026-05-29 Buy
aablocks AA00I4D1 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 98% 1mg $12 2026-05-29 Buy
aablocks AA00I4D1 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one ≥99% 200mg $24 2026-05-29 Buy
aablocks AA00I4D1 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 97% 5g $90 2026-05-29 Buy
aablocks AA00I4D1 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 97% 10g $157 2026-05-29 Buy
aablocks AA00I4D1 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 97% 25g $274 2026-05-29 Buy
AHH MT-60344 Vardenafil 98% 5g $270 2021-12-16 Buy
AHH MT-60344 Vardenafil 97% 5g $270 2026-05-25 Buy
AHH MT-60344 Vardenafil 97% 5g $270 2026-05-26 Buy
AK Scientific E429 Vardenafil 10mg $98 2021-12-16 Buy
American Custom Chemicals Corporation API0008769 VARDENAFIL 95.00% 10MG $255.15 2021-12-16 Buy
American Custom Chemicals Corporation API0008769 VARDENAFIL 95.00% 1G $722.8 2021-12-16 Buy
ApexBio Technology B3343 Vardenafil 100mg $92 2026-05-06 Buy
ApexBio Technology B3343 Vardenafil 10mg $55 2026-05-06 Buy
ApexBio Technology B3343 Vardenafil 10mM(in1mLDMSO) $61 2026-05-06 Buy

Properties

Melting point :230-235°C
Density :1.37
vapor pressure :0.001Pa at 71.34℃
Flash point :9℃
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :>22.5mg/mL in DMSO
form :Powder
pka :9.86±0.20(Predicted)
color :White to off-white
Water Solubility :7mg/L at 20℃
Henry's Law Constant :5.2×1015 mol/(m3Pa) at 25℃, HSDB (2015)
BCS Class :2
Major Application :pharmaceutical (small molecule)
InChIKey :NOIHTGOGFDFCBN-UHFFFAOYSA-N
SMILES :N12C(CCC)=NC(C)=C1C(=O)N=C(C1=CC(S(N3CCN(CC)CC3)(=O)=O)=CC=C1OCC)N2
LogP :2.5 at 23℃

Safety Information

Symbol(GHS): Flame (GHS02)Skull and Crossbones (GHS06)Health Hazard (GHS08)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.

Description

Vardenafil is a new PDE5 inhibitor launched for oral treatment of male erectile dysfunction and it has significant structural similarity with sildenafil (Viagra), which was the first PDE5 inhibitor introduced in 1998 for this indication. Vardenafil is synthesized in three steps starting with a cyclization reaction of 2-ethyoxybenzamidine with 2-butyramidopropionic acid and ethoxyallyl chloride to construct the imidazotriazine ring system, followed by sulfonation to the corresponding sulfonyl chloride and subsequent condensation with 1-ethylpiperazine. The potency of PDE5 inhibition by vardenafil (IC50=0.7 nM) is ~10 times greater than that of sildenafil (IC50=6.6 nM). Vardenafil is typically administered in single doses of 10 and 20 mg. The time to reach maximum plasma concentration is 0.75 h, which is slightly shorter than those of sildenafil (tmax=1.16 h) and tadalafil (tmax=2h), and the half-life is 4–5 h. Although it is almost completely absorbed following oral administration, the mean absolute bioavailability of a 10 mg dose is ~15%, resulting from extensive first pass metabolism. Vardenafil is metabolized in the liver primarily by CYP3A4 and is eliminated mainly in feces. In clinical studies, 10–20 mg doses of vardenafil was well tolerated and efficacious in patients with ED of various severities, including subjects with comorbidities such as diabetes mellitus or hypertension or hyperlipidemia. The side-effect profile of vardenafil is similar to that of sildenafil, with headache, flushing, dyspepsia and nasal congestion being the most common adverse events. Vardenafil has systemic vasodilatory properties, which can cause transient decrease in supine blood pressure; however, it does not appear to translate into clinical effects. The mean maximum decreases in supine systolic blood pressure following 20 and 40 mg vardenafil were 6.9 and 4.3 mmHg, respectively, when compared to placebo. However, single and multiple oral doses of vardenafil up to 40 mg produced no clinically relevant changes in the ECGs of normal male volunteers.

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