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ChemicalBook >> CAS DataBase List >> WZ4002

WZ4002

$8 - $4050
Product name: WZ4002
CAS: 1213269-23-8
MF: C25H27ClN6O3
MW: 494.97
EINECS:206-141-6
MDL Number:MFCD16621244
Synonyms:WZ4002;N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;WZ4002(HBr);N-{3-[(5-Chloro-2-{[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino}-4-pyriMidinyl)oxy]phenyl}acrylaMide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide WZ 4002;WZ 4002 N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;N-[3-[5-chloro-2-[2-Methoxy-4-(4-Methylpiperazin-1-yl)anilino]pyriMidin-4-yl]oxyphenyl]prop-2-enaMide

Price72 Properties Safety Information Description

72 prices

Selected condition：

Brand

aablocks
ACHEMBLOCK
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Axon Medchem
Biorbyt Ltd
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Sigma-Aldrich
TRC

Package

10mM(in 1mL DMSO)
1unit
EvaluationSample
10mM(in1mLDMSO)
1mg
10mg
25MG
5mg
10mM*1mLinDMSO
50MG
100mg
250.00mg
250mg
1.00g
1g
5.00g
5g

Manufactureraablocks
Product numberAA008177
Product descriptionN-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 99%
Packaging1mg
Price$8
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008177
Product descriptionN-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 99%
Packaging5mg
Price$10
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008177
Product descriptionN-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 99%
Packaging10mg
Price$12
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008177
Product descriptionN-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 98%(HPLC)
Packaging100mg
Price$32
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008177
Product descriptionN-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 98%
Packaging250mg
Price$36
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008177
Product descriptionN-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 98%
Packaging1g
Price$77
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008177
Product descriptionN-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 98%
Packaging5g
Price$239
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberM15671
Product descriptionWZ4002 98%
Packaging100MG
Price$415
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberM15671
Product descriptionWZ4002 98%
Packaging100MG
Price$415
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberM15671
Product descriptionWZ4002 98%
Packaging25MG
Price$140
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberM15671
Product descriptionWZ4002 98%
Packaging25MG
Price$140
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product numberX7482
Product descriptionWZ4002 98%(HPLC)
Packaging1g
Price$81
Updated2026-06-04
Buy

ManufacturerAK Scientific
Product numberX7482
Product descriptionWZ4002
Packaging5mg
Price$47
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberX7482
Product descriptionWZ4002 98%(HPLC)
Packaging100mg
Price$28
Updated2026-06-04
Buy

ManufacturerAK Scientific
Product numberX7482
Product descriptionWZ4002 98%(HPLC)
Packaging5g
Price$280
Updated2026-06-04
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberINB0004448
Product descriptionWZ-4002 95.00%
Packaging10MG
Price$226.8
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA008177	N-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 99%	1mg	$8	2026-05-28	Buy
aablocks	AA008177	N-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 99%	5mg	$10	2026-05-28	Buy
aablocks	AA008177	N-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 99%	10mg	$12	2026-05-28	Buy
aablocks	AA008177	N-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 98%(HPLC)	100mg	$32	2026-05-28	Buy
aablocks	AA008177	N-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 98%	250mg	$36	2026-05-28	Buy
aablocks	AA008177	N-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 98%	1g	$77	2026-05-28	Buy
aablocks	AA008177	N-[3-[[5-Chloro-2-[[2-Methoxy-4-(4-Methyl-1-Piperazinyl)Phenyl]Amino]-4-Pyrimidinyl]Oxy]Phenyl]-2-Propenamide 98%	5g	$239	2026-05-28	Buy
ACHEMBLOCK	M15671	WZ4002 98%	100MG	$415	2026-05-25	Buy
ACHEMBLOCK	M15671	WZ4002 98%	100MG	$415	2026-05-27	Buy
ACHEMBLOCK	M15671	WZ4002 98%	25MG	$140	2026-05-25	Buy
ACHEMBLOCK	M15671	WZ4002 98%	25MG	$140	2026-05-27	Buy
AK Scientific	X7482	WZ4002 98%(HPLC)	1g	$81	2026-06-04	Buy
AK Scientific	X7482	WZ4002	5mg	$47	2021-12-16	Buy
AK Scientific	X7482	WZ4002 98%(HPLC)	100mg	$28	2026-06-04	Buy
AK Scientific	X7482	WZ4002 98%(HPLC)	5g	$280	2026-06-04	Buy
American Custom Chemicals Corporation	INB0004448	WZ-4002 95.00%	10MG	$226.8	2021-12-16	Buy

Next Last

Properties

Density :1.314
storage temp. :Store at -20°C
solubility :≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :12.78±0.70(Predicted)
color :Light yellow to yellow
InChIKey :ITTRLTNMFYIYPA-UHFFFAOYSA-N
SMILES :C(NC1=CC=CC(OC2C(Cl)=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3OC)N=2)=C1)(=O)C=C

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P321	Specific treatment (see … on this label).
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P362	Take off contaminated clothing and wash before reuse.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

The recurrent missense mutation T790M in the kinase domain of epidermal growth factor receptor (EGFR) is a gatekeeper mutation, as it sterically hinders binding of inhibitors while preserving catalytic activity. WZ4002 is an irreversible EGFR tyrosine kinase inhibitor that blocks ATP-dependent autophosphorylation of EGFR carrying the T790M mutation as well as an L858R mutation (IC50 = 8 nM). It preferentially targets cells expressing EGFRT790M over those expressing EGFR without the T790M mutation. WZ4002 is also bioavailable in vivo when given intravenously and is effective in mouse models of lung cancer driven by EGFRT790M. Efficacy may be enhanced when used in combination therapy with inhibitors of Met kinase activity, Bcl-2, or histone deacetylases.

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Suppliers and manufacturers

career henan chemical co

$1.00
WZ4002 CAS:1213269-23-8

Cangzhou Wanyou New Material Technology Co.,Ltd

$1.00
WZ4002 CAS:1213269-23-8

career henan chemical co

$1.00
WZ4002 CAS:213269-23-8

TargetMol Chemicals Inc.

$44.00
WZ4002 CAS:1213269-23-8

Nanjing Gold Pharmaceutical Technology Co. Ltd.

Beijing Cooperate Pharmaceutical Co.,Ltd

Nanjing Finetech Chemical Co., Ltd.

ATK CHEMICAL COMPANY LIMITED

Biochempartner

CONIER CHEM AND PHARMA LIMITED

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WZ4002

Properties

Safety Information

Description

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