Zibotentan (ZD4054)
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- $32 - $4733
- Product name: Zibotentan (ZD4054)
- CAS: 186497-07-4
- MF: C19H16N6O4S
- MW: 424.43
- EINECS:
- MDL Number:MFCD09955343
- Synonyms:N-(3-METHOXY-5-METHYLPYRAZIN-2-YL)-2-[4-(1,3,4-OXADIAZOL-2-YL)PHENYL]PYRIDINE-3-SULFONAMIDE;3-Pyridinesulfonamide, N-(3-methoxy-5-methylpyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-;Zd 4054;Zibotentan(ZD4054);2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-N-(3-Methoxy-5-Methylpyrazin-2-yl)pyridine-3-sulfonaMide;ZD454;ZIBOTENTAN (ZD4054);ZD4054;ZD-4054;ZD 4054;ZIBOTENTAN (ZD4054) 250MG
67 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Labseeker
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 500mg
- 0.5G
- 5 mg
- 25 mg
- 1G
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA00ABJB
- Product descriptionZibotentan ≥98%
- Packaging1mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABJB
- Product descriptionZibotentan 98%
- Packaging5mg
- Price$61
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABJB
- Product descriptionZibotentan 98%
- Packaging10mg
- Price$105
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABJB
- Product descriptionZibotentan 98%
- Packaging25mg
- Price$209
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberP50897
- Product descriptionZibotentan 98%
- Packaging100MG
- Price$970
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP50897
- Product descriptionZibotentan 98%
- Packaging25MG
- Price$335
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7520
- Product descriptionZibotentan
- Packaging250mg
- Price$482
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA445755
- Product descriptionZibotentan 97%
- Packaging25mg
- Price$314
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA445755
- Product descriptionZibotentan 97%
- Packaging250mg
- Price$1120
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA445755
- Product descriptionZibotentan 97%
- Packaging5mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA445755
- Product descriptionZibotentan 97%
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005352
- Product descriptionZD-4054 95.00%
- Packaging5MG
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005352
- Product descriptionZD-4054 95.00%
- Packaging0.5G
- Price$2744.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005352
- Product descriptionZD-4054 95.00%
- Packaging1G
- Price$4036.73
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5489
- Product descriptionZibotentan (ZD4054)
- Packaging10mg
- Price$217
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA5489
- Product descriptionZibotentan (ZD4054)
- Packaging25mg
- Price$459
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00ABJB | Zibotentan ≥98% | 1mg | $36 | 2026-05-28 | Buy |
| aablocks | AA00ABJB | Zibotentan 98% | 5mg | $61 | 2026-05-28 | Buy |
| aablocks | AA00ABJB | Zibotentan 98% | 10mg | $105 | 2026-05-28 | Buy |
| aablocks | AA00ABJB | Zibotentan 98% | 25mg | $209 | 2026-05-28 | Buy |
| ACHEMBLOCK | P50897 | Zibotentan 98% | 100MG | $970 | 2026-05-27 | Buy |
| ACHEMBLOCK | P50897 | Zibotentan 98% | 25MG | $335 | 2026-05-27 | Buy |
| AK Scientific | X7520 | Zibotentan | 250mg | $482 | 2021-12-16 | Buy |
| Ambeed | A445755 | Zibotentan 97% | 25mg | $314 | 2021-12-16 | Buy |
| Ambeed | A445755 | Zibotentan 97% | 250mg | $1120 | 2021-12-16 | Buy |
| Ambeed | A445755 | Zibotentan 97% | 5mg | $109 | 2021-12-16 | Buy |
| Ambeed | A445755 | Zibotentan 97% | 10mg | $185 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005352 | ZD-4054 95.00% | 5MG | $330 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005352 | ZD-4054 95.00% | 0.5G | $2744.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005352 | ZD-4054 95.00% | 1G | $4036.73 | 2021-12-16 | Buy |
| ApexBio Technology | A5489 | Zibotentan (ZD4054) | 10mg | $217 | 2026-05-06 | Buy |
| ApexBio Technology | A5489 | Zibotentan (ZD4054) | 25mg | $459 | 2026-05-06 | Buy |
Properties
Melting point :239 - 241°C
Boiling point :637.0±65.0 °C(Predicted)
Density :1.422
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Sparingly), Methanol (Slightly)
form :Solid
pka :5.62±0.40(Predicted)
color :White to Off-White
InChI :1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
InChIKey :FJHHZXWJVIEFGJ-UHFFFAOYSA-N
SMILES :O=S(C1=C(C2=CC=C(C3=NN=CO3)C=C2)N=CC=C1)(NC4=NC=C(C)N=C4OC)=O
Boiling point :637.0±65.0 °C(Predicted)
Density :1.422
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Sparingly), Methanol (Slightly)
form :Solid
pka :5.62±0.40(Predicted)
color :White to Off-White
InChI :1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
InChIKey :FJHHZXWJVIEFGJ-UHFFFAOYSA-N
SMILES :O=S(C1=C(C2=CC=C(C3=NN=CO3)C=C2)N=CC=C1)(NC4=NC=C(C)N=C4OC)=O
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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Description
Zibotentan is a selective antagonist of the endothelin (ET) receptor type A (IC50s = 21 and >10,000 nM for human recombinant ETA and ETB, respectively). It inhibits growth of HEY, OVCA 433, SKOV3, and A2780 cells induced by endothelin 1 (ET-1; ) in vitro. Zibotentan reduces ET-1-induced expression of MMP-2, MMP-9, VEGF, COX-1 and COX-2, mediators of cell invasion and angiogenesis, in HEY cells. In vivo, zibotentan (10-50 mg/kg per day) reduces tumor growth in an HEY mouse xenograft model in a dose-dependent manner. Formulations containing zibotentan are under clinical investigation for the treatment of ovarian and castration-resistant prostate cancers.Related product price
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