α-Naphthoflavone
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- $18 - $1408.17
- Product name: α-Naphthoflavone
- CAS: 604-59-1
- MF: C19H12O2
- MW: 272.3
- EINECS:210-071-1
- MDL Number:MFCD00004985
- Synonyms:A-NAPHTHOFLAVANONE;A-NAPHTHOFLAVONE;NAPHTHOFLAVANONE, A-;NAPHTHOFLAVONE, A-;2-b)pyran-4-one,2-phenyl-4h-naphtho( ;2-b]pyran-4-one,2-phenyl-4h-naphtho[ ;2-phenyl-4h-naphtho(1,2-b)pyran-4-one ;à-naphthoflavone
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Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- SynQuest Laboratories
- TCI Chemical
- Thermo Scientific Chemicals
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- Usbiological
Package
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 1G
- 5g
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- 50g
- 0.05kg
- 100g
- 0.1kg
- 250g
- 0.25kg
- 0.5kg
- 1kg
- ManufacturerAK Scientific
- Product numberJ54118
- Product description2-Phenyl-4H-benzo[h]chromen-4-one
- Packaging5g
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberPXT0004616
- Product descriptionALPHA-NAPHTHOFLAVONE 95.00%
- Packaging5G
- Price$469.3
- Updated2021-12-16
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- ManufacturerAmerican Custom Chemicals Corporation
- Product numberPXT0004616
- Product descriptionALPHA-NAPHTHOFLAVONE 95.00%
- Packaging1G
- Price$430.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberPXT0004616
- Product descriptionALPHA-NAPHTHOFLAVONE 95.00%
- Packaging25G
- Price$746.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3353
- Product descriptionα-Naphthoflavone
- Packaging10g
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3353
- Product descriptionα-Naphthoflavone
- Packaging25g
- Price$325
- Updated2026-05-06
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- ManufacturerApexBio Technology
- Product numberC3353
- Product descriptionα-Naphthoflavone
- Packaging10g
- Price$162
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberOR1158
- Product descriptionalpha-Naphthoflavone
- Packaging5g
- Price$111
- Updated2021-12-16
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- ManufacturerApolloscientific
- Product numberOR1158
- Product descriptionalpha-Naphthoflavone
- Packaging25g
- Price$279
- Updated2021-12-16
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- ManufacturerApolloscientific
- Product numberOR1158
- Product descriptionalpha-Naphthoflavone
- Packaging100g
- Price$595
- Updated2021-12-16
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- ManufacturerApolloscientific
- Product numberOR1158
- Product descriptionalpha-Naphthoflavone 98%
- Packaging25g
- Price$166
- Updated2026-06-04
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- ManufacturerArctom
- Product numberCFN94465
- Product description7,8-Benzoflavone
- Packaging20mg
- Price$40
- Updated2021-12-16
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- ManufacturerAvaChem
- Product number4501
- Product descriptionalpha-Naphthylflavone
- Packaging20mg
- Price$39
- Updated2021-12-16
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- ManufacturerAvaChem
- Product number4501
- Product descriptionalpha-Naphthylflavone 98%
- Packaging10mg
- Price$29
- Updated2026-05-22
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- ManufacturerAvaChem
- Product number4501
- Product descriptionalpha-Naphthylflavone 98%
- Packaging20mg
- Price$39
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number4501
- Product descriptionalpha-Naphthylflavone
- Packaging10mg
- Price$29
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | J54118 | 2-Phenyl-4H-benzo[h]chromen-4-one | 5g | $20 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PXT0004616 | ALPHA-NAPHTHOFLAVONE 95.00% | 5G | $469.3 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PXT0004616 | ALPHA-NAPHTHOFLAVONE 95.00% | 1G | $430.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PXT0004616 | ALPHA-NAPHTHOFLAVONE 95.00% | 25G | $746.5 | 2021-12-16 | Buy |
| ApexBio Technology | C3353 | α-Naphthoflavone | 10g | $135 | 2021-12-16 | Buy |
| ApexBio Technology | C3353 | α-Naphthoflavone | 25g | $325 | 2026-05-06 | Buy |
| ApexBio Technology | C3353 | α-Naphthoflavone | 10g | $162 | 2026-05-06 | Buy |
| Apolloscientific | OR1158 | alpha-Naphthoflavone | 5g | $111 | 2021-12-16 | Buy |
| Apolloscientific | OR1158 | alpha-Naphthoflavone | 25g | $279 | 2021-12-16 | Buy |
| Apolloscientific | OR1158 | alpha-Naphthoflavone | 100g | $595 | 2021-12-16 | Buy |
| Apolloscientific | OR1158 | alpha-Naphthoflavone 98% | 25g | $166 | 2026-06-04 | Buy |
| Arctom | CFN94465 | 7,8-Benzoflavone | 20mg | $40 | 2021-12-16 | Buy |
| AvaChem | 4501 | alpha-Naphthylflavone | 20mg | $39 | 2021-12-16 | Buy |
| AvaChem | 4501 | alpha-Naphthylflavone 98% | 10mg | $29 | 2026-05-22 | Buy |
| AvaChem | 4501 | alpha-Naphthylflavone 98% | 20mg | $39 | 2026-05-22 | Buy |
| AvaChem | 4501 | alpha-Naphthylflavone | 10mg | $29 | 2021-12-16 | Buy |
Properties
Melting point :153-157 °C (lit.)
Boiling point :375.35°C (rough estimate)
Density :1.1382 (rough estimate)
refractive index :1.5510 (estimate)
storage temp. :2-8°C
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
form :Crystalline Powder or Crystals
color :yellow
BRN :210862
Stability :Stable. Incompatible with strong oxidizing agents.
InChI :InChI=1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H
InChIKey :VFMMPHCGEFXGIP-UHFFFAOYSA-N
SMILES :C12=C3C(C=CC=C3)=CC=C1C(=O)C=C(C1=CC=CC=C1)O2
LogP :5.003 (est)
CAS DataBase Reference :604-59-1(CAS DataBase Reference)
EPA Substance Registry System :4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl- (604-59-1)
Boiling point :375.35°C (rough estimate)
Density :1.1382 (rough estimate)
refractive index :1.5510 (estimate)
storage temp. :2-8°C
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
form :Crystalline Powder or Crystals
color :yellow
BRN :210862
Stability :Stable. Incompatible with strong oxidizing agents.
InChI :InChI=1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H
InChIKey :VFMMPHCGEFXGIP-UHFFFAOYSA-N
SMILES :C12=C3C(C=CC=C3)=CC=C1C(=O)C=C(C1=CC=CC=C1)O2
LogP :5.003 (est)
CAS DataBase Reference :604-59-1(CAS DataBase Reference)
EPA Substance Registry System :4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl- (604-59-1)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.More related product prices
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Suppliers and manufacturers
Hebei Yanxi Chemical Co., Ltd.
α-Naphthoflavone
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α-Naphthoflavone
CAS:604-59-1