1-(2-AMINO-5-MORPHOLINOPHENYL)-1-ETHANONE synthesis
- Product Name:1-(2-AMINO-5-MORPHOLINOPHENYL)-1-ETHANONE
- CAS Number:98440-50-7
- Molecular formula:C12H16N2O2
- Molecular Weight:220.27
98440-51-8
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98440-50-7
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Yield:98440-50-7 94.6%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in dichloromethane at 25; for 8 h;
Steps:
II.B.6
A solution of 57 (1.5 g, 5.9 mmol)in CH2Cl2 (30 ml) was hydrogenated in the presence of 10% Pd/C (0.4 g) at 25° C. for 8 h. The catalyst was filtered off and the filtrate was evaporated to give 60 as yellow solid. (1.25 g, 5.68 mmol); yield 94.6%; 1H-NMR (CDCl3, 200 MHz): δδ 2.45 (s, 3H), 2.9 (m, 4H), 3.68 (m, 4H), 6.67 (d, J-8.8 Hz, 1H), 6.78 (br, 2H), 7.02-7.11 (m, 2H); 13C-NMR (CDCl3, 50 MHz) δ: 200.44, 145.61, 141.51, 126.37, 119.26, 118.40, 118.22, 66.96, 51.57, 27.93; Anal. Calcd for C12H16N2O2: C, 65.43; H, 7.32; N, 12.72.
References:
US2012/15908,2012,A1 Location in patent:Page/Page column 24
99-02-5
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98440-50-7
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18640-60-3
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98440-50-7
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