1-(2-AMINOPHENYL)ETHAN-1-ONE OXIME synthesis
- Product Name:1-(2-AMINOPHENYL)ETHAN-1-ONE OXIME
- CAS Number:4964-49-2
- Molecular formula:C8H10N2O
- Molecular Weight:150.18
551-93-9
500 suppliers
$6.00/5g
4964-49-2
6 suppliers
inquiry
Yield:4964-49-2 90.3%
Reaction Conditions:
with hydroxylamine hydrochloride in ethanol at 80;Temperature;Concentration;
Steps:
4 Embodiment 4 of formula (VI) as shown in the synthesis of the compounds
For 500 ml is provided with a condensation return line, a thermometer in the four flasks are sequentially added ortho-amino-acetophenone 27g (0.2 μM), hydroxylamine hydrochloride 18.5g (0.266 μM), anhydrous ethanol 240 ml, 85 °C reflux, HPLC monitoring reaction; then cool to 20 °C, dropping 10% sodium carbonate solution, adjusting the pH=7.0 of the reaction solution, then the liquid is cooled to 10 °C, adding proper amount of water, the reaction solution becomes turbid, standing; then drop by almost 480 ml water, for 8 °C nourishing crystal 60 minutes; filtering, washing ethanol - water system, vacuum drying, get 27.09g white solid (VI) compound of formula, molar yield 90.3%, HPLC (%): 99.1%.
References:
CN104892609,2017,B Location in patent:Paragraph 0115; 0118; 0121; 0122; 0123; 0124
25384-14-9
101 suppliers
$7.00/250mg
4964-49-2
6 suppliers
inquiry
7647-01-0
0 suppliers
$10.00/10g
5653-21-4
7 suppliers
inquiry
551-93-9
500 suppliers
$6.00/5g
79965-62-1
31 suppliers
$21.00/100mg
4964-49-2
6 suppliers
inquiry
41608-06-4
0 suppliers
inquiry
7803-49-8
244 suppliers
$14.00/5mL
141-52-6
499 suppliers
$10.00/5g
4964-49-2
6 suppliers
inquiry
7647-01-0
0 suppliers
$10.00/10g
5653-21-4
7 suppliers
inquiry
7732-18-5
559 suppliers
$13.50/100ML
551-93-9
500 suppliers
$6.00/5g
79965-62-1
31 suppliers
$21.00/100mg
4964-49-2
6 suppliers
inquiry