1-Chloro-2,2-difluoropropane synthesis
- Product Name:1-Chloro-2,2-difluoropropane
- CAS Number:420-99-5
- Molecular formula:C3H5ClF2
- Molecular Weight:114.52
33420-52-9
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Yield:420-99-5 96 %
Reaction Conditions:
with bis(trichloromethyl) carbonate;triethylamine in dichloromethane at 5;
Steps:
1.3 third step:
Add 2L of dichloromethane into a 5L four-necked bottle, then add 336.3g of product A3 from the previous step, and then add 353.6g of triethylamine at one time,Then place the four-neck flask in an ice-water bath for cooling until the inner temperature of the reaction solution is 5°C.Finally, 311.6 g of solid triphosgene (BTC) was slowly added, and the stirring reaction was continued for 6 h after the addition was completed.TLC (thin layer chromatography) showed that the reaction of the raw materials was complete, and the developing solvent was petroleum ether:ethyl acetate=5:1. Finally, the reaction solution was poured into 5L of saturated sodium bicarbonate solution, stirred for half an hour and separated, and the organic phase was washed once with 2L of water.The organic phase was dried with anhydrous sodium sulfate, and then the solvent was spin-dried,384.8 g of product A4 were obtained with a yield of 96%.
References:
CN115677511,2023,A Location in patent:Paragraph 0024-0025
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