1,3,3-Trimethyl-2-methyleneindoline synthesis
- Product Name:1,3,3-Trimethyl-2-methyleneindoline
- CAS Number:118-12-7
- Molecular formula:C12H15N
- Molecular Weight:173.25
Yield:118-12-7 97.8%
Reaction Conditions:
at 180 - 220; under 22502.3 - 37503.8 Torr;Inert atmosphere;Sealed tube;Autoclave;
Steps:
1
Add 1 mol of 2,3,3-trimethyl-3H-indole and 3 mol of dimethyl carbonate to a 1L autoclave, and seal the autoclave with nitrogen for gas replacement. Then turn on the stirring, the temperature is raised to 180-220 °C, the pressure is 3.0-5.0 MPa, and the reaction is 6-8 h to the end of the reaction. Cool down and reduce pressure. Separate and recover dimethyl carbonate and by-product methanol under normal pressure and 85°C. Distill at 3-5KPa(A) under absolute pressure and 80-90°C to obtain methylated products.1,3,3-Trimethyl-2-methyleneindoline. The reaction conversion rate is 98.5%, and the quantitative product yield is 97.8%.
References:
CN112321480, 2021, A Location in patent:Paragraph 0013
5418-63-3
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118-12-7
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1640-39-7
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$6.00/5g
118-12-7
199 suppliers
$5.00/5g