1-(3-BROMOPROPOXY)-2-METHYLBENZENE synthesis
- Product Name:1-(3-BROMOPROPOXY)-2-METHYLBENZENE
- CAS Number:50912-60-2
- Molecular formula:C10H13BrO
- Molecular Weight:229.11
Yield:50912-60-2 44.1%
Reaction Conditions:
with caesium carbonate in acetonitrile; for 24 h;
Steps:
72
3-bromopropyl 2-methylphenyl ether To a solution of 2-methylphenol (0.0954 g, 0.924 mmol) in acetonitrile (4 mL) was added 1,3-dibromopropane (1.00 mL, 9.85 mmol) followed by Cs2CO3 (0.469 g, 1.44 mmol). The reaction mixture was stirred for 24 h and then concentrated under vacuum. The resulting residue was treated with H2O (4 mL) and extracted with DCM (8 mL). The organic layer was dried through a phase separator and concentrated under vacuum. The residue was taken up in DMSO and purified by preparatory HPLC (without TFA) to give the title compound (0.0934 g, 44.1%). EI-MS Rt (2.45 min).
References:
US2007/185155,2007,A1 Location in patent:Page/Page column 18
