1,4-BENZENEDIETHANOL synthesis
- Product Name:1,4-BENZENEDIETHANOL
- CAS Number:5140-03-4
- Molecular formula:C10H14O2
- Molecular Weight:166.22
7325-46-4
202 suppliers
$6.00/1g
5140-03-4
70 suppliers
$57.00/250mg
Yield:5140-03-4 87%
Reaction Conditions:
Stage #1:1,4-phenylenediacetic acid with dimethyl sulfide borane in tetrahydrofuran for 18 h;
Stage #2: with hydrogenchloride in tetrahydrofuran;water
Steps:
6.A Step A
To a stirred solution of (4-carboxymethylphenyl)acetic acid (1.0 g, 5.15 mmol) in THF (100 mL) was slowly added borane dimethyl sulfide (2.3 mL, 30.9 mmol) and the resulting mixture was stirred overnight (18 hours). The reaction was then quenched by slowly adding 1N HCl (100 mL). The resulting mixture was then extracted with EtOAc (3×100 mL). The combined organic layers were washed with saturated NaCl (1×100 mL), dried over magnesium sulfate, filtered and the solvent removed under reduced pressure to provide 750 mg of the title intermediate (87% yield), which was used without further purification.
References:
Theravance, Inc. US2005/203167, 2005, A1 Location in patent:Page/Page column 21
36076-25-2
17 suppliers
inquiry
5140-03-4
70 suppliers
$57.00/250mg
36076-26-3
86 suppliers
$26.00/1g
5140-03-4
70 suppliers
$57.00/250mg
39246-00-9
14 suppliers
inquiry
5140-03-4
70 suppliers
$57.00/250mg
95-71-6
421 suppliers
$9.00/25g
5140-03-4
70 suppliers
$57.00/250mg