1,4-BENZODIOXAN-6-CARBOXALDEHYDE synthesis
- Product Name:1,4-BENZODIOXAN-6-CARBOXALDEHYDE
- CAS Number:29668-44-8
- Molecular formula:C9H8O3
- Molecular Weight:164.16
Yield:29668-44-8 97%
Reaction Conditions:
with caesium carbonate in DMF (N,N-dimethyl-formamide) at 70; for 16 h;
Steps:
42.a
Example 42; - preparation of 5-f f2,3-dihydro-f .41-benzodioxin)-6-vimethvf)amino}-N- (2-r2-dimethvlamino )ethvll-1 H-benzordelisoguinolin-1,3(2H)-dione; The synthetic route of this compound proceeds in a series of steps schematically shown in attached figure 2 and is described in more details as follows; a); in a first step, 500 mg 3,4-dihydroxybenzaldehyde, 2.6 g cesium carbonate (2 equivalents), 1.4 g 1,2-dibromoethane (2 equivalents) and 5 mL anhy-drous DMF were stirred at 70°C for 16 hours. After cooling, the solvent was evaporated under reduced pressure and the residue was submitted to a flash chromatography (Si02, eluent : CH2CI2), thus resulting in 575.3 mg (yield : 97 %) of the intermediate shown as product A in figure 2 ;
References:
WO2005/105753,2005,A2 Location in patent:Page/Page column 63-64
82102-37-2
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