1,6-Dichlorohexane synthesis
- Product Name:1,6-Dichlorohexane
- CAS Number:2163-00-0
- Molecular formula:C6H12Cl2
- Molecular Weight:155.07
629-11-8
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2163-00-0
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Yield:2163-00-0 96%
Reaction Conditions:
with hydrogenchloride;ammonium chloride in water at 50 - 110; for 3 h;Reagent/catalyst;
Steps:
1; 1-4 Example 1 The preparation method of 1,6-dichlorohexane, the steps as follows:
Into a 1000ml reaction flask with oil-water separator and condenser,Put in 400 grams of water, 5 grams of ammonium chloride, and 500 grams of 1,6-hexanediol in sequence, and stir and raise the temperature to 50°C;Start to pass HCL gas, when the clear and transparent reaction liquid in the reaction flask becomes milky white,Continue to pass HCL gas, increase the temperature of the reaction solution to 110°C, and start refluxing and liquid separation;As the reflux reaction progresses, there is stratification in the oil-water separator, and the reflux reaction is 3 hours.The molar ratio of 1,6-hexanediol to HCL gas is 1:2.5; the lower water phase is refluxed into the reaction flask, and the upper oil layer is 1,6-dichlorohexane separated and collected.The purity was 99.6% by HPLC, and the yield based on 1,6-dichlorohexane was 96%.
References:
CN112341309,2021,A Location in patent:Paragraph 0018; 0022-0025
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2163-00-0
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