1-Boc-3,3-dimethylpiperazine synthesis
- Product Name:1-Boc-3,3-dimethylpiperazine
- CAS Number:259808-67-8
- Molecular formula:C11H22N2O2
- Molecular Weight:214.3
24424-99-5
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259808-67-8
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Yield: 96%
Reaction Conditions:
in dichloromethane at 0 - 20; for 4 h;
Steps:
4.C
To a solution of 2,2-dimethylpiperazine (400 mg) in dichloromethane (20 mL) at 0° C. was added di-tert-butyl dicarbonate (766 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL) and extracted into dichloromethane (2*40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4) and concentrated to give 3,3-diemethyl-piperazine-1-carboxylic acid tert-butyl ester as a white solid (720 mg, 96%).
References:
Piramed Limited;Genentech, Inc. US2008/76758, 2008, A1 Location in patent:Page/Page column 90
58632-95-4
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84477-72-5
156 suppliers
$13.00/100mg
259808-67-8
122 suppliers
$15.00/100mg