一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1-BROMO-5-FLUORO-2-METHOXY-3-NITROBENZENE
179897-92-8

1-BROMO-5-FLUORO-2-METHOXY-3-NITROBENZENE synthesis

2synthesis methods
-

Yield: 61.8%

Reaction Conditions:

with potassium carbonate in acetone at 80; for 22 h;

Steps:

2.2
Step 2 1-Bromo-5-fluoro-2-methoxy-3-nitro-benzene; 2-Bromo-4-fluoro-6-nitro-phenol 2b (24.7 g, 104.7 mmol) and potassium carbonate (17.34 g, 125.6 mmol) were dissolved in 300 mL of acetone followed by addition of iodomethane (9.8 mL, 157.1 mmol). The reaction mixture was heated to reflux at 80 °C for 22 hours. The reaction was monitored by TLC until the disappearance of the starting materials. The mixture was concentrated under reduced pressure and diluted with 200 mL of ethyl acetate and 200 mL of water. The aqueous layer was extracted with ethyl acetate (100 mL ×2). The combined organic extracts were washed with 4 N hydrochloric acid and saturated aqueous sodium bicarbonate and dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain the title compound 1-bromo-5-fluoro-2-methoxy-3-nitro-benzene 2c (16.18 g, yield 61.8%) as a white solid. MS m/z (ESI): 252 [M+1] 1H NMR (CDCl3): δ 3.99 (s, 3H), 7.81 (d, J = 8.0 Hz, 1H), 7.28 (q, J = 8.0 Hz, 4.0 Hz, 1H), 7.89 (q, J = 8.0 Hz, 4.0 Hz, 1H)

References:

Jiangsu Hengrui Medicine Co., Ltd.;Shanghai Hengrui Pharmaceutical Co. Ltd. EP2236500, 2010, A1 Location in patent:Page/Page column 17-18

1-BROMO-5-FLUORO-2-METHOXY-3-NITROBENZENE Related Search:

雷山县| 龙州县| 商城县| 门源| 遵化市| 延长县| 德兴市| 卢龙县| 广安市| 大名县| 茌平县| 乐亭县| 溧阳市| 临夏县| 瑞昌市| 大埔区| 陵水| 广饶县| 贞丰县| 乌鲁木齐县| 濮阳县| 六盘水市| 广河县| 沐川县| 阳东县| 图们市| 建宁县| 镇赉县| 台南县| 平武县| 浙江省| 阿图什市| 普定县| 乐清市| 隆尧县| 开原市| 盐津县| 乌海市| 邵阳县| 惠安县| 楚雄市|