1-Bromocyclododecane synthesis
- Product Name:1-Bromocyclododecane
- CAS Number:7795-35-9
- Molecular formula:C12H23Br
- Molecular Weight:247.21
1724-39-6
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Yield:7795-35-9 37%
Reaction Conditions:
with phosphorus tribromide at 100; for 2 h;
Steps:
19 Preparation Example 19 (3e)
Under air, add cyclododecanol (1.84g, 10.0mmol) to the reaction bottle equipped with a stir bar, and dissolve by heating at 100 .Phosphorus tribromide (470 μL, 5.0 mmol) was added, and after the addition, the reaction was continued for 2 h.TLC detected the reaction was complete, the system was poured into ice water to quench, extracted with ethyl acetate, washed with saturated sodium bicarbonate solution,Wash with saturated sodium chloride solution, dry with anhydrous sodium sulfate, concentrate, silica gel column chromatography, eluent is petroleum ether,The product is 912.0 mg of colorless liquid with a yield of 37%.
References:
CN111099941,2020,A Location in patent:Paragraph 0180-0182
1501-82-2
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294-62-2
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294-62-2
110 suppliers
$15.00/5g
7795-35-9
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1724-39-6
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$7.00/5g
830-13-7
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