Yield:166526-05-2 81%

Reaction Conditions:

Stage #1: cyclopropyl bromidewith iodine;magnesium in diethyl ether;Cooling with ice;
Stage #2: (N-methyl-N-methoxy)methoxyacetamide in diethyl ether at 0 - 20; for 1.5 h;
Stage #3: with hydrogenchloride;water in diethyl ether; for 0.25 h;

References:

Hartz, Richard A.;Ahuja, Vijay T.;Arvanitis, Argyrios G.;Rafalski, Maria;Yue, Eddy W.;Denhart, Derek J.;Schmitz, William D.;Ditta, Jonathan L.;Deskus, Jeffrey A.;Brenner, Allison B.;Hobbs, Frank W.;Payne, Joseph;Lelas, Snjezana;Li, Yu-Wen;Molski, Thaddeus F.;Mattson, Gail K.;Peng, Yong;Wong, Harvey;Grace, James E.;Lentz, Kimberley A.;Qian-Cutrone, Jingfang;Zhuo, Xiaoliang;Shu, Yue-Zhong;Lodge, Nicholas J.;Zaczek, Robert;Combs, Andrew P.;Olson, Richard E.;Bronson, Joanne J.;Mattson, Ronald J.;Macor, John E. [Journal of Medicinal Chemistry,2009,vol. 52,# 14,p. 4173 - 4191] Location in patent:experimental part