1-(DIPHENYLMETHYL)-3-METHOXYAZETIDINE synthesis
- Product Name:1-(DIPHENYLMETHYL)-3-METHOXYAZETIDINE
- CAS Number:36476-82-1
- Molecular formula:C17H19NO
- Molecular Weight:253.34
18621-17-5
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36476-82-1
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$70.00/5g
Yield:36476-82-1 92%
Reaction Conditions:
with sodium hydride in DMF (N,N-dimethyl-formamide) at 0 - 20; for 2 h;
Steps:
78a Example 78(a): 1-Benzhydryl-3-methoxy-azetidine
To an ice cold [SOLUTION OF 1-BENZHYDRYLAZETIDIN-3-OL 9A] (1.0 g, 4.2 mmole) in DMF (10 ml) was added 60% dispersion NaH in mineral oil (0.25 g, 6.3 mmole). After 30min at [0°C,] [5ML] more DMF was added along with methyl iodide (0.39 [ML,] 6.3 [MMOLE).] The ice bath was removed, and the reaction was stirred at room temperature (rt). After 1.5hr, the reaction was poured into brine and extracted with Et2O (2x). The combined organic layers were washed with brine, dried [(MGS04)] and concentrated under reduced pressure. The residue was flash chromatographed on silica gel eluting Hexanes/EtOAc (1: 1) to give 919mg (92%) of a colorless oil which crystallized on [STANDING.'H NMR (DMSO-D6) S 7.] 42 (4H, d, [J = 7. 3 HZ),] 7.27 (4H, t, [J=7. 3HZ),] 7.13 (2H, t, [J=7. 3HZ),] 4.39 [(1H,] s), 3.95 [(1H,] p, [J=5. 8HZ),] 3.35 (2H, t, J = 6. 3 Hz), 3.11 (3H, s), 2.75 (2H, t, [J = 5. 6 HZ).]
References:
WO2003/106462,2003,A1 Location in patent:Page 113; 114
74-88-4
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$15.00/10g
36476-82-1
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$70.00/5g
90604-02-7
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36476-82-1
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$70.00/5g
33301-41-6
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$13.50/250mg
124-41-4
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36476-82-1
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67-56-1
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33301-41-6
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124-41-4
720 suppliers
$12.00/25g
36476-82-1
31 suppliers
$70.00/5g