1-Methyl-2-piperidinemethanol synthesis
- Product Name:1-Methyl-2-piperidinemethanol
- CAS Number:20845-34-5
- Molecular formula:C7H15NO
- Molecular Weight:129.2
98303-20-9
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20845-34-5
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Yield:-
Reaction Conditions:
with LiAlH4 in tetrahydrofuran;
Steps:
10 1-Methyl-2-piperidinemethanol
EXAMPLE 10 1-Methyl-2-piperidinemethanol The title compound of Example 9 (23.2 g, 101 mmol) in dry THF (100 mL) was added dropwise to a 1.0M solution of LiAlH4 in THF (405 mL, 405 mmol, 4eq) and the reaction mixture was refluxed overnight and the product was isolated as described in Example 6 to give the product (13.1 g, quantative) as a colorless oil. The fumarate salt crystallized from 2-propanol: mp 118°-120° C.; 1 H-NMR (CDCl3) ⅆ3.85 (dd, J=gem=11 Hz, J=3.9 Hz, 1H), 3,39 (dd, J=gem=11 Hz, J=2.2 Hz, 1H), 2.89 (m, 1H), 2.30 (s, 3H), 2.15 (m, 1H), 1.97 (m, 1H), 1.76 (m, 1H), 1.42-1.68 (complex m, 4H), 1.28 (m, 1H); CIMS (MH+ calcd for C7 H15 NO): 130. Found (MH+): 130; Anal. (C11 H19 NO5): C,H,N.
References:
US5571832,1996,A
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