1-phenyl-1H-pyrazol-5-ol synthesis
- Product Name:1-phenyl-1H-pyrazol-5-ol
- CAS Number:876-93-7
- Molecular formula:C9H8N2O
- Molecular Weight:160.17
34846-90-7
100-63-0
876-93-7
To three 100 mL reaction bottles were added 10.8 g (100 mmol) of phenylhydrazine and 11.6 g (100 mmol) of methyl 3-methoxyacrylate, followed by 100 mL of methanol as solvent. The reaction mixture was heated to reflux and kept reacting for about 6 hours. Upon completion of the reaction, the reaction solution was quantitatively analyzed by high performance liquid chromatography (HPLC) and the yield of 1-phenyl-5-hydroxypyrazole was measured to be 85.7%.
34846-90-7
279 suppliers
$7.00/5g
100-63-0
377 suppliers
$10.00/1g
876-93-7
32 suppliers
$158.55/250mg
Yield:876-93-7 85.7%
Reaction Conditions:
in methanol; for 6 h;Reflux;
Steps:
2
To three reaction bottles were added 10.8 g (100 mmol) of phenylhydrazine, 11.6 g (100 mmol) of methyl methacrylate,100 mL of methanol. The temperature of the reaction mixture was raised to reflux for about 6 hours. The reaction liquid was quantified by liquid chromatography, and 1-phenyl-5-hydroxypyrazoleYield 85.7%.
References:
CN104059020,2016,B Location in patent:Paragraph 0016; 0017