1-Propanamine, 3-methoxy-N-(phenylmethylene)- synthesis
- Product Name:1-Propanamine, 3-methoxy-N-(phenylmethylene)-
- CAS Number:105427-51-8
- Molecular formula:C11H15NO
- Molecular Weight:177.24
Yield:105427-51-8 99.43%
Reaction Conditions:
with 18-crown-6 ether;potassium hydroxide in toluene at -10 - -5; for 6 h;
Steps:
1.2
The 162.0 g of A1 was added to 500 g of toluene solvent, then 18-Crown-6 phase transfer catalyst (6 mmol, 1.62 g, 0.6%), KOH (1.5 mol, 84 g) was added and the reaction system was controlled at a temperature between -5 - 10 ° C . then dropwise addition of methyl iodide (1. 1 mol, 157 g) , dropwise addition was over at 2.5 h, and the reaction was completed at 3.5 h. then added 100g of water, extracted to separate liquid, the toluene layer was washed once with 50 g of water, and toluene layer was distilled to remove toluene to obtain 174 g of white solid B1; the yield was 99.43% and the purity was 99.15%.
References:
CN106631832,2017,A Location in patent:Paragraph 0058
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