一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List TERT-BUTOXYCARBONYLAMINO-(2,4-DIFLUORO-PHENYL)-ACETIC ACID
1025496-16-5

TERT-BUTOXYCARBONYLAMINO-(2,4-DIFLUORO-PHENYL)-ACETIC ACID synthesis

2synthesis methods
Carbamic acid, N-[2-amino-1-(2,4-difluorophenyl)-2-oxoethyl]-, 1,1-dimethylethyl ester

1194752-50-5
1 suppliers
inquiry

TERT-BUTOXYCARBONYLAMINO-(2,4-DIFLUORO-PHENYL)-ACETIC ACID

1025496-16-5
21 suppliers
inquiry

-

Yield:1025496-16-5 10.5 g

Reaction Conditions:

with water;sodium hydroxide in methanol at 75; for 12 h;

Steps:

134 2-((tert-butoxycarbonyl)amino)-2-(2,4-difluorophenyl)acetic acid (KE)

To a stirred solution of compound KD (11.0 g, 38.46 mmol) in MeOH (100 mL) was added NaOH (3.1 g, 76.92 mmol) in water (50 mL) at RT and the reaction mixture was stirred at 75C for 12 h. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue was quenched with water and washed with EtOAc. The aqueous layer was treated with 2N HC1 to pH 3 and the product was extracted with EtOAc. The combined organic layer was washed with water and brine, dried over anhydrous Na2S04 and concentrated under reduced pressure to afford compound KE (10.5 g, 95.1%) as an off white solid. LC-MS: m/z 188.0 [M+l-boc]+.

References:

WO2018/165520,2018,A1 Location in patent:Page/Page column 255-256

河西区| 荃湾区| 高陵县| 基隆市| 江川县| 天气| 北安市| 汉中市| 安康市| 衡阳市| 彭泽县| 锡林郭勒盟| 吕梁市| 库伦旗| 红河县| 荣成市| 东光县| 三原县| 青岛市| 河西区| 清涧县| 盐津县| 德昌县| 汕尾市| 合阳县| 商城县| 平山县| 丹寨县| 翼城县| 眉山市| 梁平县| 浦江县| 大名县| 焉耆| 新源县| 诸暨市| 西林县| 阳朔县| 保康县| 尉氏县| 梅河口市|