一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile
1029714-87-1

2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile synthesis

12synthesis methods
6-((2-(4-bromo-3-fluorophenyl)imidazo[1,2-b][1,2,4]triazin-7-yl)methyl)quinoline

1029714-86-0
2 suppliers
inquiry

2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile

1029714-87-1
13 suppliers
inquiry

-

Yield:1029714-87-1 90%

Reaction Conditions:

with N,N,N,N,-tetramethylethylenediamine;tris-(dibenzylideneacetone)dipalladium(0);4,5-bis(diphenylphosphino)-9,9-dimethylxanthene in N,N-dimethyl-formamide at 160; for 0.138889 h;Sealed tube;Microwave irradiation;

Steps:

7.9

Zinc cyanide (131 mg, 1.11 mmol), tris(dibenzylideneacetone)dipalladium(0) (35 mg, 0.038 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (78.5 mg, 0.136 mmol), and N,N,N'N'-Tetramethylethylenediamine (0.22 mL, 1.4 mmol) were added successively to a mixture of 6-[2-(4-bromo-3-fluorophenyl)imidazo[l,2-b][l,2,4]-triazin-7-yl]methylquinoline (480 mg, 1.10 mmol) in N,N-dimethylformamide (8.7 mL) in a microwave tube. The tube was sealed and degassed three times and heated to 160 0C under microwave irradiation for 500 s. Most of the solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate, washed with aqueous sodium bicarbonate, water and brine, and dried over magnesium sulfate. Filtration and concentration afforded a residue which was purified on a silica gel column with methanol in dichloromethane (0-6 %) to give the desired product. (90%) LCMS: (M+H) = 381.0.

References:

WO2008/64157,2008,A1 Location in patent:Page/Page column 44

1197377-47-1 Synthesis
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile

1197377-47-1
74 suppliers
inquiry

1197377-31-3 Synthesis
1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione

1197377-31-3
51 suppliers
inquiry

2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile

1029714-87-1
13 suppliers
inquiry

垫江县| 海伦市| 武鸣县| 花垣县| 香河县| 韶关市| 久治县| 察雅县| 临西县| 察雅县| 封丘县| 封丘县| 武川县| 湄潭县| 武川县| 安阳县| 罗城| 甘德县| 林周县| 昆山市| 呈贡县| 灵石县| 马龙县| 西青区| 吉水县| 甘洛县| 三穗县| 阿坝| 梁山县| 达日县| 平江县| 彝良县| 治多县| 南召县| 鹤岗市| 庆元县| 新宁县| 霍州市| 闽清县| 永安市| 蓬溪县|