(S)-1-Boc-2-(Hydroxymethyl)piperazine synthesis
- Product Name:(S)-1-Boc-2-(Hydroxymethyl)piperazine
- CAS Number:1030377-21-9
- Molecular formula:C10H20N2O3
- Molecular Weight:216.28
385802-84-6
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1030377-21-9
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Yield:1030377-21-9 91.82%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20; for 3 h;
Steps:
55.1 Step 1:
Step 1:
(S)-tert-butyl 2-(hydroxymethyl)piperazine-1-carboxylate
To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL) was added 10% Pd/C (150 mg).
The mixture was stirred at rt for 3 h under H2.
Then the solid was remove by filtration and the filter was concentrated to give (S)-tert-butyl 2-(hydroxymethyl)piperazine-1-carboxylate (850 mg, 3.93 mmol, 91.82%) as a white solid. ESI-MS (EI+, m/z): 217.3 [M+H]+.
References:
US2018/127370,2018,A1 Location in patent:Paragraph 1006; 1004
149715-45-7
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366003-57-8
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149648-97-5
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930837-02-8
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1030377-21-9
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