TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
- CAS Number:1056934-87-2
- Molecular formula:C12H16ClN3O2
- Molecular Weight:269.73
![6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one](/CAS/GIF/109229-22-3.gif)
109229-22-3
99 suppliers
$129.00/1g
1056934-87-2
97 suppliers
$184.00/250mg
Yield:-
Steps:
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 18 h / 760.05 Torr / Inert atmosphere
2: triphenylphosphine; tetrachloromethane / 1,2-dichloro-ethane / 2.5 h / 70 °C
References:
Meredith, Erik L.;Mainolfi, Nello;Poor, Stephen;Qiu, Yubin;Miranda, Karl;Powers, James;Liu, Donglei;Ma, Fupeng;Solovay, Catherine;Rao, Chang;Johnson, Leland;Ji, Nan;Artman, Gerald;Hardegger, Leo;Hanks, Shawn;Shen, Siyuan;Woolfenden, Amber;Fassbender, Elizabeth;Sivak, Jeremy M.;Zhang, Yiqin;Long, Debby;Cepeda, Rosemarie;Liu, Fang;Hosagrahara, Vinayak P.;Lee, Wendy;Tarsa, Peter;Anderson, Karen;Elliott, Jason;Jaffee, Bruce [Journal of Medicinal Chemistry,2015,vol. 58,# 23,p. 9273 - 9285]
41276-30-6
98 suppliers
$61.96/1g
1056934-87-2
97 suppliers
$184.00/250mg