4-(4-ISOPROPYLPIPERIZINYL)PHENYLBORONIC ACID, PINACOL ESTER synthesis
- Product Name:4-(4-ISOPROPYLPIPERIZINYL)PHENYLBORONIC ACID, PINACOL ESTER
- CAS Number:1073354-18-3
- Molecular formula:C19H31BN2O2
- Molecular Weight:330.27
73183-34-3
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844431-60-3
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$45.00/10mg
1073354-18-3
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Yield:1073354-18-3 4.2 g
Reaction Conditions:
with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;potassium acetate in toluene at 110;Inert atmosphere;
Steps:
368.4 Step 4: 1-isopropyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)phenyl) piperazine
[01003] 1-(4-Bromophenyl)-4-isopropylpiperazine (4.3 g, 15.19 mmol) was dissolved in degassed toluene (43 mL). To this, potassium acetate (5.88 g, 60 mmol), bis(pinacolato)diboron (6.5 g, 25.67 mmol) and Pd(dppf)CI2.DCM complex (1.22 g, 1.44 mmol) were added under nitrogen atmosphere and the reaction mass was stirred at 110 °C for 4 h. The volatiles were removed under reduced pressure to give crude product (4.2 g) as a black solid which was used as such in next step without further purification. LCMS: [M+H] + = 331.46.
References:
WO2022/226668,2022,A1 Location in patent:Paragraph 01000; 01003
66698-28-0
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1073354-18-3
49 suppliers
$55.00/50mg