4-Chloro-2-methoxy-5-nitro-benzoic acid methyl ester synthesis
- Product Name:4-Chloro-2-methoxy-5-nitro-benzoic acid methyl ester
- CAS Number:109069-75-2
- Molecular formula:C9H8ClNO5
- Molecular Weight:245.62
68255-77-6
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Yield:-
Reaction Conditions:
with sodium chloride;sulfuric acid in methanol;
Steps:
P.103 Methyl 4-mercapto-5-nitro-o-anisate
Production Example 103 Methyl 4-mercapto-5-nitro-o-anisate To a solution of 3.1 g of 4-chloro-5-nitro-o-anisic acid in methanol (100 ml) was added a catalytic amount of sulfuric acid and the resulting mixture was heated under reflux for 3 hours. Then the reaction mixture was poured into ice/water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, 3.3 g of methyl 4-chloro-5-nitro-o-anisate was obtained as pale yellow crystals.
References:
US6518423,2003,B1
67-56-1
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