(1E,3E)-1,3-Butadiene-1,4-dicarboxylic acid dimethyl ester synthesis
- Product Name:(1E,3E)-1,3-Butadiene-1,4-dicarboxylic acid dimethyl ester
- CAS Number:1119-43-3
- Molecular formula:C8H10O4
- Molecular Weight:170.16
692-92-2
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1119-43-3
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Yield:1119-43-3 100%
Reaction Conditions:
iodine in acetonitrile; for 25 h;Product distribution / selectivity;Reflux;
Steps:
27
Example 27Synthesis of trans,trans Dimethyl Muconate from cis,trans Dimethyl Muconate A solution of cis,trans dimethyl muconate (0.60 g, 3.53 mmol) and a catalytic amount of iodine (43 mg, 4.8 mole percent) in acetonitrile (10 ml) is heated to reflux for 25 hours. The reaction is performed in the presence of ambient light in the laboratory. Removal of all solvent on a rotary evaporator is followed by applying a high vacuum, washing with 15 ml diethyl ether and hexane in a 3/2 volumetric ratio to remove all iodine, and drying under high vacuum yields an off-white crystalline solid (0.60 g, 3.53 mmol, 100 percent yield) which is identified as pure trans,trans dimethyl muconate.
References:
US2010/314243,2010,A1 Location in patent:Page/Page column 22
292638-85-8
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1119-43-3
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554-12-1
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$21.00/25mL
1119-43-3
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6214-22-8
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$45.00/50mg
1119-43-3
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