(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester synthesis
- Product Name:(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester
- CAS Number:1168152-06-4
- Molecular formula:C21H19NO5
- Molecular Weight:365.38
108-24-7
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1663-61-2
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1168152-06-4
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Yield:1168152-06-4 82%
Reaction Conditions:
at 110; for 4 h;
Steps:
1 Intermediate A: (E)-Methyl 1 -acetyl-3-(ethoxy(phenyl)methylene)-2-oxoindoline-6- carboxylate
To a stirred solution of methyl 2-oxoindoline-6-carboxylate (1.00 g, 5.23 mmol) in acetic anhydride (10.9 mL, 1 15 mmol) was added (triethoxymethyl)benzene (3.55 mL, 15.7 mmol) and the mixture was stirred at 1 10 °C for 4 h. The reaction mixture was cooled to rt and the resulting precipitate collected by filtration. The precipitate was washed with hexanes (100 mL) and dried in vacuo to afford the subtitle compound (￡)-methyl 1-acetyl-3- (ethoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate as a beige solid (1.66 g, 82%); Rl 2.61 min (Method 1); m/z 366 (M+H)+ (ES+).
References:
WO2017/109513,2017,A1 Location in patent:Page/Page column 26
676326-36-6
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1663-61-2
197 suppliers
$10.00/5g
1168152-06-4
16 suppliers
$230.00/250mg