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ChemicalBook CAS DataBase List ethyl 2-amino-4-(4-pyridinyl)-3-thiophenecarboxylate
117516-88-8

ethyl 2-amino-4-(4-pyridinyl)-3-thiophenecarboxylate synthesis

3synthesis methods
-

Yield:117516-88-8 75 %

Reaction Conditions:

Stage #1: methyl (4-pyridyl) ketone;ethyl 2-cyanoacetatewith morpholine in ethanol at 80;
Stage #2: with sulfur in ethanol;Inert atmosphere;Reflux;

References:

Mohammadian, Esmaeil;Oghabi Bakhshaiesh, Tayebeh;Jouyban, Abolghasem;Nazeri, Elahe;Hasanvand, Zaman;Moghimi, Setareh;Motahari, Rasoul;Firoozpour, Loghman;Bijanzadeh, Hamidreza;Alizadeh Sani, Mahmood;Hosseinzadeh, Elaheh;Esmaeili, Rezvan;Foroumadi, Alireza [Archiv der Pharmazie,2023,vol. 356,# 3,art. no. 2200349]

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