tert-Butyl 7-broMo-3,4-dihydroquinoline-1(2H)-carboxylate synthesis
- Product Name:tert-Butyl 7-broMo-3,4-dihydroquinoline-1(2H)-carboxylate
- CAS Number:1187932-64-4
- Molecular formula:C14H18BrNO2
- Molecular Weight:312.2
14548-39-1
324 suppliers
$10.00/1g
1187932-64-4
52 suppliers
$50.00/50mg
Yield:-
Steps:
Multi-step reaction with 4 steps
1: hydroxylamine hydrochloride; potassium hydroxide / water; methanol / 3 h / Reflux
2: methanesulfonyl chloride; triethylamine / dichloromethane / 2 h / -15 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C
4: dmap; triethylamine / tetrahydrofuran / 60 °C
References:
Koehler, Michael F. T.;Bergeron, Philippe;Choo, Edna F.;Lau, Kevin;Ndubaku, Chudi;Dudley, Danette;Gibbons, Paul;Sleebs, Brad E.;Rye, Carl S.;Nikolakopoulos, George;Bui, Chinh;Kulasegaram, Sanji;Kersten, Wilhelmus J. A.;Smith, Brian J.;Czabotar, Peter E.;Colman, Peter M.;Huang, David C. S.;Baell, Jonathan B.;Watson, Keith G.;Hasvold, Lisa;Tao, Zhi-Fu;Wang, Le;Souers, Andrew J.;Elmore, Steven W.;Flygare, John A.;Fairbrother, Wayne J.;Lessene, Guillaume [ACS Medicinal Chemistry Letters,2014,vol. 5,# 6,p. 662 - 667]
24424-99-5
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$13.50/25G
114744-51-3
140 suppliers
$33.00/100mg
1187932-64-4
52 suppliers
$50.00/50mg
14548-51-7
89 suppliers
$37.00/250mg
1187932-64-4
52 suppliers
$50.00/50mg