12-HYDROXYSTEARIC ACID ETHYL ESTER synthesis
- Product Name:12-HYDROXYSTEARIC ACID ETHYL ESTER
- CAS Number:74815-67-1
- Molecular formula:C20H40O3
- Molecular Weight:328.53
Yield:74815-67-1 96%
Reaction Conditions:
with sulfuric acid at 78; for 20 h;Heating / reflux;
Steps:
1; 3; 4; 5; 6; 7 ETHVL 12-HVDROXVSTEARATE
Technical grade 12-hydroxystearic acid (purchased from Aldrich) was purified to >99% by extraction with hexane. 150 mmol (45 g) of the purified 12-hydroxystearic acid and 5 mmol (0.5 g) sulfuric acid was dissolved in 300 ML ethanol in a 500 ML round flask with a Dimroth condenser and refluxed at 78 °C for 20 hours. The product was isolated by solvent evaporation and subsequent dissolution in 300 ml methyl tert-butyl ether (hereinafter MTBE). The liquid was extracted with water (3X100 ml) and then evaporated. The product was recovered in 96% isolated yield (47. 8 g).
References:
WO2004/89869,2004,A1 Location in patent:Page 14-15; 17; 18; 19; 20; 22
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