METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE synthesis
- Product Name:METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
- CAS Number:120034-05-1
- Molecular formula:C7H6BrNO3
- Molecular Weight:232.03
10128-91-3
120 suppliers
$9.00/250mg
120034-05-1
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$7.00/250mg
Yield: 40%
Reaction Conditions:
with N-Bromosuccinimide in dichloromethane at 50; for 48 h;
Steps:
15.1 Step 1 : Synthesis ofmethyl-5-bromo-2-oxo-l.2-dihvdropyridine-3-carboxylate
Methyl 2-hydroxynicotinate (500 mg, 3.27 mmol) and N-bromosuccinimide (756 mg, 4.25 mmol) were dissolved in dichloromethane and the mixture was stirred at 50 °C for 48 hours. The mixture was cooled to room temperature and then concentrated under reduced pressure. The resulting residue was filtered with a small amount of dichloromethane to obtain the title compound (0.3 g, yield: 40%, yellow solid). *H NMR (500MHz, DMSO-d6) d 8.07 (d, J = 5.0 Hz, 1H), 7.98 (d, J = 5.0 Hz, 1H), 3.75 (s, 3H)
References:
WELLMARKER BIO CO., LTD.;LEE, Hyunho;PARK, Chun-Ho;HUR, Sun Chul;MOON, Jai-Hee;SHIN, Jae-Sik;HONG, Seung-Woo;PARK, Yoon-Sun;KIM, Joseph;LEE, Sohee;KIM, Hyojin;PARK, Hyebin WO2019/182274, 2019, A1 Location in patent:Page/Page column 31-32
10128-91-3
120 suppliers
$9.00/250mg
120034-05-1
125 suppliers
$7.00/250mg
609-71-2
390 suppliers
$5.00/5g
120034-05-1
125 suppliers
$7.00/250mg