1-(4-BroMo-phenyl)-cyclopentanecarboxylic acid Methyl ester synthesis
- Product Name:1-(4-BroMo-phenyl)-cyclopentanecarboxylic acid Methyl ester
- CAS Number:1236357-64-4
- Molecular formula:C13H15BrO2
- Molecular Weight:283.16
628-21-7
234 suppliers
$6.00/1g
41841-16-1
221 suppliers
$5.00/5g
1236357-64-4
39 suppliers
$45.00/10mg
Yield:1236357-64-4 47%
Reaction Conditions:
with sodium hydride in tetrahydrofuran;mineral oil at 20;Inert atmosphere;
Steps:
Preparation of Intermediate methyl 1-(4-bromoDhenyl)cvclθDentanecarboxylate (1AF-1); Methyl 2-(4-bromophenyl)acetate (73.Og, 0.32mol) was dissolved in tetrahydrofuran (75OmL) and 1 ,4-diiodobutane (25.5g, 0.64mol) was added. The mixture was stirred under a flow of argon and sodium hydride (60% on oil, 100.Og, 0.32mol) was added slowly in portions. After the addition was complete, the mixture was stirred at room temperature for 16 hours. The mixture was poured onto ice-cold water (50OmL) and ethyl acetate was added (50OmL). The mixture was separated and the aqueous layer washed with ethyl acetate (50OmL). The organic layers were combined and washed with brine (1 L), dried over magnesium sulfate and concentrated to give methyl 1-(4- bromophenyl)cyclopentanecarboxylate (42.Og, 47%) as a yellow solid.1 H NMR (CDCI3, 400MHz): 7.41 (d, 2H), 7.22 (d, 2H), 3.59 (s, 3H), 2.55-2.66 (m, 2H), 1.81-1.90 (m, 2H), 1.68-1.75 (m, 4H).
References:
WO2010/86820,2010,A1 Location in patent:Page/Page column 52-53
110-52-1
573 suppliers
$9.00/1g
41841-16-1
221 suppliers
$5.00/5g
1236357-64-4
39 suppliers
$45.00/10mg
1878-68-8
511 suppliers
$6.00/10g
1236357-64-4
39 suppliers
$45.00/10mg
41841-16-1
221 suppliers
$5.00/5g
1236357-64-4
39 suppliers
$45.00/10mg