一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

1325681-81-9

1-(2-Methylbenzoyl)-N-phenyl-1H-indazole-3-carboxamide synthesis

3synthesis methods
1H-indazole-3-carboxylic acid phenylamide

23706-99-2
5 suppliers
inquiry

1-(2-Methylbenzoyl)-N-phenyl-1H-indazole-3-carboxamide

1325681-81-9
4 suppliers
inquiry

-

Yield:1325681-81-9 20%

Reaction Conditions:

with triethylamine in dichloromethane at 0 - 20;

Steps:

5.1.1. General procedures for 3a-k, 3m, and 3q

General procedure: To a cooled (0 °C) suspension of 1H-indazole-3-carboxylic acid phenylamide 234 (0.42 mmol) and a catalytic amount of Et3N (0.05 mL) in anhydrous CH2Cl2 (1-2 mL), the appropriate aroyl chloride (1.25 mmol) was added. The mixture was stirred for 1-2 h at 0 °C and then for 1-3 h at room temperature. The precipitate was filtered off, and the solvent was evaporated in vacuo. Cold water (20 mL) was added, the mixture was neutralized with 0.5 N NaOH, and the precipitate was recovered by vacuum filtration. For compounds 3c, 3e-f, 3k, and 3q, the reaction mixture was extracted with CH2Cl2 (3 × 15 mL) after dilution. The solvent was dried over sodium sulphate to obtain the desired final compounds. Compound 3c was purified by column chromatography using toluene/ethyl acetate 8:2 as eluent.

References:

Crocetti, Letizia;Giovannoni, Maria Paola;Schepetkin, Igor A.;Quinn, Mark T.;Khlebnikov, Andrei I.;Cilibrizzi, Agostino;Piaz, Vittorio Dal;Graziano, Alessia;Vergelli, Claudia [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 15,p. 4460 - 4472] Location in patent:experimental part

顺昌县| 勃利县| 化德县| 柘城县| 唐海县| 庆元县| 赞皇县| 台北市| 建昌县| 通榆县| 疏附县| 肇庆市| 乡宁县| 新邵县| 肃宁县| 武定县| 阳山县| 镇远县| 大关县| 梧州市| 津南区| 穆棱市| 阿坝| 酒泉市| 疏附县| 四会市| 合水县| 鄂托克前旗| 马龙县| 宿松县| 襄汾县| 翼城县| 昌黎县| 兴和县| 长泰县| 方城县| 鄂州市| 新晃| 东乡| 台中县| 梁平县|