3-FLUORO-4-(1-METHYL-5,6-DIHYDRO-1H-[1,2,4]TRIAZIN-4-YL)-PHENYLAMINE(WXG00213) synthesis
- Product Name:3-FLUORO-4-(1-METHYL-5,6-DIHYDRO-1H-[1,2,4]TRIAZIN-4-YL)-PHENYLAMINE(WXG00213)
- CAS Number:1334167-69-9
- Molecular formula:C10H13FN4
- Molecular Weight:208.24
1334167-66-6
20 suppliers
inquiry
1334167-69-9
8 suppliers
inquiry
Yield: 97%
Reaction Conditions:
with hydrogen;palladium-on-charcoal in methanol at 20; for 4 h;
Steps:
1.V
Synthesis of Compound VThe compound IV (34.5 g, 145 mmol) was put into MeOH (400 mL), and 10% Pd/C (10 g) was added thereto. Then, a flask was equipped with a hydrogen balloon, and the reactant was stirred for 4 hours at room temperature. Pd/C was removed through filtering under reduced pressure using celite, and the filtrate was concentrated under reduced pressure, thereby obtaining Compound V (29.3 g, 97%) as orange solid.1H NMR (600 MHz, chloroform-d1) δ=6.92 (t, J=9.0 Hz, 1H), 6.77 (s, 1H), 6.44-6.39 (m, 2H), 3.78 (br s, 2H), 3.73 (t, J=4.8 Hz, 2H), 2.94 (t, J=4.8 Hz, 2H), 2.77 (s, 3H)LCMS: 209 (M+H+) for C10H13-FN4
References:
LEGOCHEM BIOSCIENCES, INC. US2013/5967, 2013, A1 Location in patent:Page/Page column 6
369-34-6
426 suppliers
$5.00/5g
1334167-69-9
8 suppliers
inquiry
1334167-62-2
1 suppliers
inquiry
1334167-69-9
8 suppliers
inquiry
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
1334167-69-9
8 suppliers
inquiry
1334167-59-7
3 suppliers
inquiry
1334167-69-9
8 suppliers
inquiry